dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000297
Uniprot Accession O08605; MKNK1_MOUSE;
Genbank Protein ID NP_001272417.1; NP_067436.1;
Genbank Nucleotide ID NM_001285488.1; NM_021461.5;
Protein Name MAP kinase-interacting serine/threonine-protein kinase 1
Protein Synonyms/Alias MAP kinase signal-integrating kinase 1;MAPK signal-integrating kinase 1;Mnk1;
Gene Name Mknk1
Gene Synonyms/Alias Mnk1;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
34RRKKKRKTRATDSLPdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus15234964; 16381945; 23193290; 22135298
39RKTRATDSLPGKFEDdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus15234964; 16381945; 23193290; 22135298
180PENILCESPEKVSPVdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 19060867; 22135298; 21743459;
185CESPEKVSPVKICDFdbPTM 3.0;PhosphoSitePlus;UniProt;curated21183079; 16381945; 23193290; 22135298; 21743459; 25338131
203SGVKLNNSCTPITTPdbPTM 3.0;PhosphoSitePlus16162500; 16381945; 23193290; 22135298
209NSCTPITTPELTTPCdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt9155017; 16381945; 23193290; 10022874; 17724079; 17906627; 1
214ITTPELTTPCGSAEYdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt9155017; 16381945; 23193290; 10022874; 17724079; 17906627; 1
344APERGLPTPQVLQRNdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated9155017; 16381945; 23193290; 18055695; 22135298; 23984901
372IALNRQLSQHEENELPhosphoSitePlus;curated22135298; 25338131
392ALAEGLCSMKLSPPScurated25338131
396GLCSMKLSPPSKSRLdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated16162500; 21183079; 16381945; 23193290; 19060867; 22135298;
399SMKLSPPSKSRLARRPhosphoPep 2.019060867
415ALAQAGRSRDANPCLcurated25338131
Sequence
(Fasta)		MVSSQKLEKP IEMGSSEPLP IVDSDKRRKK KRKTRATDSL PGKFEDVYQL TSELLGEGAY 60
AKVQGAVNLQ SGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNRNILEL IEFFEDDTRF 120
YLVFEKLQGG SILAHIQKRK HFNEREASRV VRDVATALDF LHTKGIAHRD LKPENILCES 180
PEKVSPVKIC DFDLGSGVKL NNSCTPITTP ELTTPCGSAE YMAPEVVEVF RDEATFYDKR 240
CDLWSLGVVL YIMLSGYPPF VGHCGADCGW DRGEVCRMCQ NKLFESIQEG KYEFPDKDWA 300
HISNEAKDLI SKLLVRDAKQ RLSAAQVLQH PWVQGQAPER GLPTPQVLQR NSSTMDLTLF 360
AAEAIALNRQ LSQHEENELA EEQEALAEGL CSMKLSPPSK SRLARRRALA QAGRSRDANP 420
CLTPAGL 428
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0810--Translation regulation
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0009931--F:calcium-dependent protein serine/threonine kinase activity
GO:0005516--F:calmodulin binding
GO:0004683--F:calmodulin-dependent protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand
GO:0035556--P:intracellular signal transduction
GO:0018105--P:peptidyl-serine phosphorylation
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0006417--P:regulation of translation
GO:0009651--P:response to salt stress