| Tag |
Content |
| dbPAF ID |
dbPAF-0000293 |
| Uniprot Accession |
O08601; MTP_MOUSE; B2CXA7; Q3UJA0; Q91X33;
|
| Genbank Protein ID |
NP_001156929.1; NP_032668.2; XP_006501165.1; XP_006501166.1;
|
| Genbank Nucleotide ID |
NM_001163457.1; NM_008642.2; XM_006501102.2; XM_006501103.2;
|
| Protein Name |
Microsomal triglyceride transfer protein large subunit |
| Protein Synonyms/Alias |
|
| Gene Name |
Mttp |
| Gene Synonyms/Alias |
Mtp; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets.Functional Description
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MILLAVLFLC FFSSYSASVK GHTTGLSLNN ERLYKLTYST EVFLDGGKGK PQDSVGYKIS 60
SDVDVVLLWR NPDGDDDQVI QVTITAVNVE NAGQQRGEKS IFQGKSTPKI IGKDNLEALQ 120
RPMLLHLVRG KVKEFYSYEN EPVGIENLKR GLASLFQMQL SSGTTNEVDI SGDCKVTYQA 180
QQDKVVKIKA LDTCKIERSG FTTANQVLGV SSKATSVTTY KIEDSFVTAV LAEETRAFAL 240
NFQQTIAGKI VSKQKLELKT TEAGPRMIPG KQVAGVIKAV DSKYKAIPIV GQVLERVCKG 300
CPSLAEHWKS IRKNLEPENL SKAEAVQSFL AFIQHLRTSR REEILQILKA EKKEVLPQLV 360
DAVTSAQTPD SLEAILDFLD FKSDSSIILQ ERFLYACGFA THPDEELLRA LLSKFKGSFA 420
SNDIRESVMI IIGALVRKLC QNEGCKLKAV VEAKKLILGG LEKPEKKEDT TMYLLALKNA 480
LLPEGIPLLL KYAEAGEGPV SHLATTVLQR YDVSFITDEV KKTLNRIYHQ NRKVHEKTVR 540
TTAAAVILKN PSYMDVKNIL LSIGELPKEM NKYMLTVVQD ILHFEMPASK MIRRVLKEMA 600
VHNYDRFSKS GSSSAYTGYV ERSPRAASTY SLDILYSGSG ILRRSNLNIF QYIGKAELHG 660
SQVVIEAQGL EGLIAATPDE GEENLDSYAG MSAILFDVQL RPVTFFNGYS DLMSKMLSAS 720
GDPVSVVKGL ILLIDHSQDI QLQSGLKANM EIQGGLAIDI SGSMEFSLWY RESKTRVKNR 780
VAVVITSDVT VDASFVKAGV ESRAETEAGL EFISTVQFSQ YPFLVCMQMD KAEAPLRQFE 840
TKYERLSTGR GYVSRRRKES LVAGCELPLH QENSEMCNVV FPPQPESDNS GGWF
895Fasta Sequence
>O08601|Mttp|Mus musculus(Mouse)
MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFLDGGKGKPQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIFQGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQLSSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVTTYKIEDSFVTAVLAEETRAFALNFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGVIKAVDSKYKAIPIVGQVLERVCKGCPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQERFLYACGFATHPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVLQRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNPSYMDVKNILLSIGELPKEMNKYMLTVVQDILHFEMPASKMIRRVLKEMAVHNYDRFSKSGSSSAYTGYVERSPRAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDIQLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKAGVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRRRKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF
|
| Keyword |
KW-0877--Alternative promoter usage
KW-0153--Cholesterol metabolism
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0443--Lipid metabolism
KW-0446--Lipid-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0753--Steroid metabolism
KW-1207--Sterol metabolism
KW-0813--Transport
|
| Interpro |
IPR015819--Lipid_transp_b-sht_shell
IPR001747--Lipid_transpt_N
IPR015816--Vitellinogen_b-sht_N
IPR011030--Vitellinogen_superhlx
|
| PROSITE |
PS51211--VITELLOGENIN
|
| Pfam |
PF01347--Vitellogenin_N
|
| Gene Ontology |
GO:0016323--C:basolateral plasma membrane
GO:0031526--C:brush border membrane
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0031988--C:membrane-bounded vesicle
GO:0031528--C:microvillus membrane
GO:0043235--C:receptor complex
GO:0005791--C:rough endoplasmic reticulum
GO:0008289--F:lipid binding
GO:0005319--F:lipid transporter activity
GO:0005548--F:phospholipid transporter activity
GO:0046982--F:protein heterodimerization activity
GO:0042632--P:cholesterol homeostasis
GO:0008203--P:cholesterol metabolic process
GO:0007623--P:circadian rhythm
GO:0006629--P:lipid metabolic process
GO:0042157--P:lipoprotein metabolic process
GO:0042953--P:lipoprotein transport
GO:0015914--P:phospholipid transport
GO:0034377--P:plasma lipoprotein particle assembly
GO:0006497--P:protein lipidation
GO:0051592--P:response to calcium ion
GO:0006641--P:triglyceride metabolic process
GO:0034197--P:triglyceride transport
|
