dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000292
Uniprot Accession O08599; STXB1_MOUSE; A2ARS2; A2ARS3; A2ARS4; Q5WAC6; Q8VD51;
Genbank Protein ID NP_001107041.1; NP_033321.2;
Genbank Nucleotide ID NM_001113569.1; NM_009295.2;
Protein Name Syntaxin-binding protein 1
Protein Synonyms/Alias Protein unc-18 homolog 1;Unc18-1;Protein unc-18 homolog A;Unc-18A;
Gene Name Stxbp1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 29 (View all)
PositionPeptidesSourceReferences ( PMIDs )
42QLSMRMLSSCCKMTDPhosphoSitePlus22135298
43LSMRMLSSCCKMTDIPhosphoSitePlus22135298
107RAAHVFFTDSCPDALdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.015572359; 16381945; 23193290; 22135298; 19366988
142IAFLPYESQVYSLDSdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.015572359; 16381945; 23193290; 22135298; 19366988
145LPYESQVYSLDSADSdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.015572359; 16381945; 23193290; 22135298; 19366988
146PYESQVYSLDSADSFdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.015572359; 16381945; 23193290; 22135298; 19366988
269DVYKYETSGIGEARVPhosphoSitePlus22135298
306VSQEVTRSLKDFSSSdbPTM 3.0;Phospho.ELM 9.012519779; 16381945; 23193290
313SLKDFSSSKRMNTGEdbPTM 3.0;Phospho.ELM 9.012950453; 12519779; 16381945; 23193290
344YQKELSKYSTHLHLAdbPTM 3.0;SysPTM 2.017203969; 16381945; 23193290; 19366988
345QKELSKYSTHLHLAEdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.015572359; 16381945; 23193290; 17203969; 22135298; 19366988
346KELSKYSTHLHLAEDdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.015572359; 16381945; 23193290; 22135298; 19366988
454GVPIVTDSTLRRRSKPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22807455
455VPIVTDSTLRRRSKPdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated21183079; 16381945; 23193290; 21081558; 22135298; 22807455
473ERISEQTYQLSRWTPdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.018034455; 16381945; 23193290; 15592455; 22135298; 19366988
479TYQLSRWTPIIKDIMPhosphoSitePlus22135298
501LDTKHYPYISTRSSAPhosphoSitePlus22135298
506YPYISTRSSASFSTTPhosphoPep 2.0;curated19060867; 25338131
507PYISTRSSASFSTTAdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17242355; 16381945; 23193290; 19060867; 22135298; 19366988;
509ISTRSSASFSTTAVSdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17114649; 16381945; 23193290; 21183079; 22135298; 19366988;
Sequence
(Fasta)		MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI MTEGITIVED 60
INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR AAHVFFTDSC PDALFNELVK 120
SRAAKVIKTL TEINIAFLPY ESQVYSLDSA DSFQSFYSPH KAQMKNPILE RLAEQIATLC 180
ATLKEYPAVR YRGEYKDNAL LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS 240
SPVLHELTFQ AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS 300
QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL AEDCMKHYQG 360
TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS TYDKIRIILL YIFLKNGITE 420
ENLNKLIQHA QIPPEDSEII TNMAHLGVPI VTDSTLRRRS KPERKERISE QTYQLSRWTP 480
IIKDIMEDTI EDKLDTKHYP YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF 540
ILGGVSLNEM RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS 595
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR027482--Sec-1-like_dom2
IPR001619--Sec1-like
PROSITE
Pfam

PF00995--Sec1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0043209--C:myelin sheath
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0031091--C:platelet alpha granule
GO:0043234--C:protein complex
GO:0043195--C:terminal bouton
GO:0044822--F:poly(A) RNA binding
GO:0019905--F:syntaxin binding
GO:0017075--F:syntaxin-1 binding
GO:0007412--P:axon target recognition
GO:0006887--P:exocytosis
GO:0060292--P:long term synaptic depression
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0032229--P:negative regulation of synaptic transmission, GABAergic
GO:0007274--P:neuromuscular synaptic transmission
GO:0007269--P:neurotransmitter secretion
GO:0070527--P:platelet aggregation
GO:0002576--P:platelet degranulation
GO:0045956--P:positive regulation of calcium ion-dependent exocytosis
GO:0072659--P:protein localization to plasma membrane
GO:0050821--P:protein stabilization
GO:0015031--P:protein transport
GO:0010807--P:regulation of synaptic vesicle priming
GO:0031629--P:synaptic vesicle fusion to presynaptic membrane
GO:0016188--P:synaptic vesicle maturation
GO:0006904--P:vesicle docking involved in exocytosis