dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000291
Uniprot Accession O08593; PDE7A_RAT;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Protein Synonyms/Alias Rolipram-insensitive phosphodiesterase type 7;
Gene Name Pde7a
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
57RNIRRLLSFQRYLRSPhosphoSitePlus22135298
Sequence
(Fasta)
DQTALYIRML GDVRVRSRAG FETERRGSHP YIDFRIFHAQ SEIEASVSAR NIRRLLSFQR 60
YLRSSRFFRG ATVCRSLNIL DEDYNGQAKC MLEKVGNWNF DIFLFDRLTN GNSLVSLTFH 120
LFSLHGLIEY FHLDMVKLRR FLVMIQEDYH SQNPYHNAVH AADVTQAMHC YLKEPKLANS 180
VTPWDILLSL IAAATHDLDH PGVNQPFLIK TNHYLATLYK NTSVLENHHW RSAVGLLRES 240
GLFSHLPLES RHEMEAQIGA LILATDISRQ NEYLSLFRSH LDKGDLHLDD GRHRHLVLQM 300
ALKCADICNP CRNWELSKQW SEKVTEEFFH QGDIEKKYHL GVSPLCDRQT ESIANIQIGF 360
MTYLQEPLFT EWARFSDTRL SQTMLGHVGL NKASWKGLQR QQPSSEDASA AFELNSQLLT 420
QENRLS 427
Keyword

KW-0114--cAMP
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR003607--HD/PDEase_dom
IPR023088--PDEase
IPR002073--PDEase_catalytic_dom
IPR023174--PDEase_CS

PROSITE

PS00126--PDEASE_I

Pfam

PF00233--PDEase_I

Gene Ontology

GO:0004115--F:3',5'-cyclic-AMP phosphodiesterase activity
GO:0004112--F:cyclic-nucleotide phosphodiesterase activity
GO:0046872--F:metal ion binding
GO:0006198--P:cAMP catabolic process
GO:0019933--P:cAMP-mediated signaling