dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000290
Uniprot Accession O08589; PLM_RAT;
Genbank Protein ID XP_006228901.1; XP_008757406.1;
Genbank Nucleotide ID XM_006228839.2; XM_008759184.1;
Protein Name Phospholemman
Protein Synonyms/Alias FXYD domain-containing ion transport regulator 1;
Gene Name Fxyd1
Gene Synonyms/Alias Plm;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
70KFNQQQRTGEPDEEEcurated24945867
79EPDEEEGTFRSSIRRdbPTM 3.0;PhosphoSitePlus;curated19700791; 16381945; 23193290; 22135298; 22817900
82EEEGTFRSSIRRLSTcurated23984901; 24945867
83EEGTFRSSIRRLSTRdbPTM 3.0;PhosphoSitePlus;curated16434394; 19339511; 21849407; 22535957; 7999001; 16381945; 2
88RSSIRRLSTRRR---dbPTM 3.0;PhosphoSitePlus16434394; 16608841; 17283221; 19339511; 21849407; 22535957;
89SSIRRLSTRRR----dbPTM 3.0;PhosphoSitePlus19339511; 21849407; 22535957; 16381945; 23193290; 22135298
Sequence
(Fasta)		MASPGHILIV CVCLLSMASA EAPQEPDPFT YDYHTLRIGG LTIAGILFIL GILIILSKRC 60
RCKFNQQQRT GEPDEEEGTF RSSIRRLSTR RR 93
Keyword

KW-0868--Chloride
KW-0869--Chloride channel
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0407--Ion channel
KW-0406--Ion transport
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR000272--Ion-transport_regulator_FXYD
PROSITE

PS01310--FXYD
Pfam

PF02038--ATP1G1_PLM_MAT8
Gene Ontology

GO:0005901--C:caveola
GO:0034707--C:chloride channel complex
GO:0005829--C:cytosol
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0042383--C:sarcolemma
GO:0051117--F:ATPase binding
GO:0005254--F:chloride channel activity
GO:0017022--F:myosin binding
GO:0017080--F:sodium channel regulator activity
GO:0007420--P:brain development
GO:0051480--P:cytosolic calcium ion homeostasis
GO:1903797--P:positive regulation of inorganic anion transmembrane transport
GO:0032892--P:positive regulation of organic acid transport
GO:1903278--P:positive regulation of sodium ion export from cell
GO:0086004--P:regulation of cardiac muscle cell contraction
GO:0086036--P:regulation of cardiac muscle cell membrane potential
GO:2000649--P:regulation of sodium ion transmembrane transporter activity