dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000289
Uniprot Accession O08587; NUP50_RAT; Q4QR93;
Genbank Protein ID NP_037123.1;
Genbank Nucleotide ID NM_012991.1;
Protein Name Nuclear pore complex protein Nup50
Protein Synonyms/Alias 50 kDa nucleoporin;Nuclear pore-associated protein 60 kDa-like;Nucleoporin Nup50;
Gene Name Nup50
Gene Synonyms/Alias Npap60;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
235STKLQQDSPFSFHGNPhosphoSitePlus;curated22135298; 22276854
313AAQSKAASSPFSAKAcurated23984901
Sequence
(Fasta)
MAKRVAEKEL TDRNWDEEDE VEEMGTFSVA SEEVMKNRAV KKAKRRNIGF ESDSGGAFKG 60
FKGLVVPSGG GGFSGFGGGS GGKPLEGLTN GNSTDSATPF SSAKTAAEPK AAFGSFAVNG 120
PTTLVDKKIS SPKCNSSNQP PSSGPASSTS CTGNTYHKQL AGLNCSVRDW IVKHVNTNPL 180
CDLTPIFKDY ERYLATIEKQ LENGGSSSSE RQTDRATAAM EPPSLFGSTK LQQDSPFSFH 240
GNKAEDTSEK LEFTAEKKSD AAQGATSASF NFGKKIESSV LGSLSSGSLT GFSFSPGNSS 300
LFGKDAAQSK AASSPFSAKA SESQAGGSSS ECRDGEEEES DEPPKVVVTE VKEEDAFYSK 360
KCKLFYKKDN EFKEKGVGTL HLKPTATQKT QLLVRADTNL GNILLNVLIP PNMPCTRTGK 420
NNVLIVCVPN PPLDEKQPTL PVTMLIRVKT SEDADELHKI LLQKKDV 468
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport

Interpro

IPR015007--NUP2/50/61
IPR011993--PH/PTB_dom
IPR000156--Ran_bind_dom

PROSITE

PS50196--RANBD1

Pfam

PF08911--NUP50
PF00638--Ran_BP1

Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0046907--P:intracellular transport
GO:0051028--P:mRNA transport
GO:0015031--P:protein transport