dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000289 | ||||||||||||
| Uniprot Accession | O08587; NUP50_RAT; Q4QR93; | ||||||||||||
| Genbank Protein ID | NP_037123.1; | ||||||||||||
| Genbank Nucleotide ID | NM_012991.1; | ||||||||||||
| Protein Name | Nuclear pore complex protein Nup50 | ||||||||||||
| Protein Synonyms/Alias | 50 kDa nucleoporin;Nuclear pore-associated protein 60 kDa-like;Nucleoporin Nup50; | ||||||||||||
| Gene Name | Nup50 | ||||||||||||
| Gene Synonyms/Alias | Npap60; | ||||||||||||
| Organism | Rattus norvegicus(Rat) | ||||||||||||
| NCBI Taxa ID | 10116 | ||||||||||||
| Functional Description (View all) |
Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MAKRVAEKEL TDRNWDEEDE VEEMGTFSVA SEEVMKNRAV KKAKRRNIGF ESDSGGAFKG 60 FKGLVVPSGG GGFSGFGGGS GGKPLEGLTN GNSTDSATPF SSAKTAAEPK AAFGSFAVNG 120 PTTLVDKKIS SPKCNSSNQP PSSGPASSTS CTGNTYHKQL AGLNCSVRDW IVKHVNTNPL 180 CDLTPIFKDY ERYLATIEKQ LENGGSSSSE RQTDRATAAM EPPSLFGSTK LQQDSPFSFH 240 GNKAEDTSEK LEFTAEKKSD AAQGATSASF NFGKKIESSV LGSLSSGSLT GFSFSPGNSS 300 LFGKDAAQSK AASSPFSAKA SESQAGGSSS ECRDGEEEES DEPPKVVVTE VKEEDAFYSK 360 KCKLFYKKDN EFKEKGVGTL HLKPTATQKT QLLVRADTNL GNILLNVLIP PNMPCTRTGK 420 NNVLIVCVPN PPLDEKQPTL PVTMLIRVKT SEDADELHKI LLQKKDV 468 |
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| Keyword | KW-0007--Acetylation |
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| Interpro | IPR015007--NUP2/50/61 |
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| PROSITE | PS50196--RANBD1 |
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| Pfam | |||||||||||||
| Gene Ontology | GO:0031965--C:nuclear membrane |