dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000284
Uniprot Accession O08582; GTPB1_MOUSE; Q3UD96; Q3UGW6; Q545R1; Q80ZY5;
Genbank Protein ID NP_038846.2;
Genbank Nucleotide ID NM_013818.2;
Protein Name GTP-binding protein 1
Protein Synonyms/Alias
Gene Name Gtpbp1
Gene Synonyms/Alias Gtpbp;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
6--MAAERSRSPVDSPdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 16381945; 23193290; 20531401; 21183079; 21659605;
8MAAERSRSPVDSPVPdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 16381945; 23193290; 19737024; 20139300; 21183079;
12RSRSPVDSPVPASMFdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 16381945; 23193290; 18388127; 21183079; 21659605;
17VDSPVPASMFAPEPSdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18388127; 21183079; 16381945; 23193290; 19060867; 22135298;
24SMFAPEPSSPGAARAdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 18388127; 20531401; 21183079; 21659605; 16381945;
25MFAPEPSSPGAARAAdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17114649; 16381945; 23193290; 18056256; 20139300; 20415495;
44RLHGGFDSDCSEDGEdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated17242355; 19367708; 16381945; 23193290; 19854140; 20415495;
47GGFDSDCSEDGEALNdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated17242355; 19367708; 16381945; 23193290; 19854140; 21183079;
69TSKLVLVSPTSEQYDdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated20415495; 16381945; 23193290; 21081558; 22135298; 22817900;
72LVLVSPTSEQYDSLLdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated20415495; 16381945; 23193290; 21081558; 22135298; 22817900
580LLQTTNNSPMNSKPQdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19854140; 20415495; 21183079; 21659605; 16381945; 23193290;
600STKKGPLSKREEGGPPhosphoSitePlus22135298
658GQRHKVKSGACVTPAcurated25266776
Sequence
(Fasta)		MAAERSRSPV DSPVPASMFA PEPSSPGAAR AAAAAARLHG GFDSDCSEDG EALNGEPELD 60
LTSKLVLVSP TSEQYDSLLR QMWERMDEGC GETIYVIGQG SDGTEYGLSE ADMEASYATV 120
KSMAEQIEAD VILLRERQEA GGRVRDYLVR KRVGDNDFLE VRVAVVGNVD AGKSTLLGVL 180
THGELDNGRG FARQKLFRHK HEIESGRTSS VGNDILGFDS EGNVVNKPDS HGGSLEWTKI 240
CEKSSKVITF IDLAGHEKYL KTTVFGMTGH LPDFCMLMVG SNAGIVGMTK EHLGLALALN 300
VPVFVVVTKI DMCPANILQE TLKLLQRLLK SPGCRKIPVL VQSKDDVIVT ASNFSSERMC 360
PIFQISNVTG ENLDLLKMFL NLLSPRTSYR EEEPAEFQID DTYSVPGVGT VVSGTTLRGL 420
IKLNDTLLLG PDPLGNFLSI AVKSIHRKRM PVKEVRGGQT ASFALKKIKR SSIRKGMVMV 480
SPRLNPQASW EFEAEILVLH HPTTISPRYQ AMVHCGSIRQ TATILSMDKD CLRTGDKATV 540
HFRFIKTPEY LHIDQRLVFR EGRTKAVGTI TKLLQTTNNS PMNSKPQQIK MQSTKKGPLS 600
KREEGGPCGV PAAGGPPTGD EASSLGTAQA ASTSGLQPQP KPSSGGRRRG GQRHKVKSGA 660
CVTPASGC 669
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0342--GTP-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR027417--P-loop_NTPase
IPR000795--TF_GTP-bd_dom
IPR009000--Transl_B-barrel
IPR009001--Transl_elong_EF1A/Init_IF2_C
PROSITE

PS51722--G_TR_2
Pfam
Gene Ontology

GO:0000177--C:cytoplasmic exosome (RNase complex)
GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0016020--C:membrane
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0044822--F:poly(A) RNA binding
GO:0003743--F:translation initiation factor activity
GO:0061014--P:positive regulation of mRNA catabolic process
GO:0006413--P:translational initiation