dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000282
Uniprot Accession O08580; ERR1_MOUSE; B2RRU9; Q3U110;
Genbank Protein ID NP_031979.2;
Genbank Nucleotide ID NM_007953.2;
Protein Name Steroid hormone receptor ERR1
Protein Synonyms/Alias Estrogen receptor-like 1;Estrogen-related receptor alpha;ERR-alpha;Nuclear receptor subfamily 3 group B member 1;
Gene Name Esrra
Gene Synonyms/Alias Err1;Estrra;Nr3b1;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
19YIKAEPASPDSPKGSdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 18063693; 16381945; 23193290; 17676930; 19854140;
22AEPASPDSPKGSSETdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17676930; 21183079; 21659605; 16381945; 23193290; 17242355;
26SPDSPKGSSETETEPdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated21183079; 21659605; 16381945; 23193290; 17242355; 19060867;
27PDSPKGSSETETEPPdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated21183079; 16381945; 23193290; 17242355; 19060867; 22135298;
29SPKGSSETETEPPVTPhosphoPep 2.019060867
31KGSSETETEPPVTLAPhosphoSitePlus;curated22135298; 23567750
36TETEPPVTLASGPAPdbPTM 3.0;PhosphoSitePlus;curated21183079; 16381945; 23193290; 22135298
61EDGEGAGSGEQGSGKPhosphoSitePlus;curated22135298; 20469934
Sequence
(Fasta)		MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVTLASG PAPARCLPGH KEEEDGEGAG 60
SGEQGSGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE 120
CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP 180
LAVAGGPRKT APVNALVSHL LVVEPEKLYA MPDPASPDGH LPAVATLCDL FDREIVVTIS 240
WAKSIPGFSS LSLSDQMSVL QSVWMEVLVL GVAQRSLPLQ DELAFAEDLV LDEEGARAAG 300
LGDLGAALLQ LVRRLQALRL EREEYVLLKA LALANSDSVH IEDAEAVEQL REALHEALLE 360
YEAGRAGPGG GAERRRAGRL LLTLPLLRQT AGKVLAHFYG VKLEGKVPMH KLFLEMLEAM 420
MD 423
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR027289--Oest-rel_rcp
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA
PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2
Pfam

PF00104--Hormone_recep
PF00105--zf-C4
Gene Ontology

GO:0045171--C:intercellular bridge
GO:0015630--C:microtubule cytoskeleton
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0051216--P:cartilage development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042127--P:regulation of cell proliferation
GO:0045667--P:regulation of osteoblast differentiation
GO:0045670--P:regulation of osteoclast differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006366--P:transcription from RNA polymerase II promoter