dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000281
Uniprot Accession O08579; EMD_MOUSE; Q3TIH6; Q3UJP3;
Genbank Protein ID NP_031953.1;
Genbank Nucleotide ID NM_007927.3;
Protein Name Emerin
Protein Synonyms/Alias
Gene Name Emd
Gene Synonyms/Alias Sta;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 26 (View all)
PositionPeptidesSourceReferences ( PMIDs )
8MDDYAVLSDTELAAVcurated25338131
29PHGPIVGSTRKLYEKdbPTM 3.0;PhosphoSitePlus;curated21659604; 16381945; 23193290; 22135298; 25266776
56LPPNSSSSSFSYQFScurated25338131
60SSSSSFSYQFSDLDSPhosphoSitePlus22135298
63SSFSYQFSDLDSAAVcurated23984901
75AAVDSDMYDLPKKEDdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16857009; 16381945; 23193290; 22135298; 22817900
86KKEDALLYQSKDYNDPhosphoSitePlus;curated22135298; 22817900
88EDALLYQSKDYNDDYdbPTM 3.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18846507; 19367708; 19854140; 16381945; 23193290; 21081558;
95SKDYNDDYYEESYLTdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16857009; 16381945; 23193290; 18515860; 22135298; 22817900
96KDYNDDYYEESYLTTdbPTM 3.0;PhosphoSitePlus;curated18515860; 16381945; 23193290; 22135298; 22817900
105ESYLTTKTYGEPESVdbPTM 3.0;PhosphoSitePlus;curated18515860; 16381945; 23193290; 22135298; 22817900
106SYLTTKTYGEPESVGdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated16857009; 16381945; 23193290; 18515860; 22135298; 22817900
111KTYGEPESVGMSKSFcurated25338131
117ESVGMSKSFRQPGTSdbPTM 3.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18846507; 19854140; 16381945; 23193290; 21081558; 22135298;
123KSFRQPGTSLVDADTcurated25266776
124SFRQPGTSLVDADTFdbPTM 3.0;PHOSIDA;SysPTM 2.0;curated18846507; 16381945; 23193290; 21081558; 19366988; 22817900;
141QVRDDIFSSLEEEGKdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated19854140; 16381945; 23193290; 18846507; 21081558; 19060867;
142VRDDIFSSLEEEGKDdbPTM 3.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18846507; 19854140; 16381945; 23193290; 21081558; 22135298;
155KDRERLIYGQDSAYQPhosphoSitePlus22135298
159RLIYGQDSAYQSIAHPhosphoSitePlus22135298
Sequence
(Fasta)		MDDYAVLSDT ELAAVLRQYN IPHGPIVGST RKLYEKKIFE YETQRRRLLP PNSSSSSFSY 60
QFSDLDSAAV DSDMYDLPKK EDALLYQSKD YNDDYYEESY LTTKTYGEPE SVGMSKSFRQ 120
PGTSLVDADT FHHQVRDDIF SSLEEEGKDR ERLIYGQDSA YQSIAHYRPI SNVSRSSLGL 180
SYYPTSSTSS VSSSSSSPSS WLTRRAIRPE KQAPAAALGQ DRQVPLWGQL LLFLVFAAFL 240
LFVYYSIQAE EGNPFWMDP
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0472--Membrane
KW-0493--Microtubule
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR011015--LEM/LEM-like_dom
IPR003887--LEM_dom
PROSITE

PS50954--LEM
Pfam

PF03020--LEM
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005635--C:nuclear envelope
GO:0005637--C:nuclear inner membrane
GO:0005652--C:nuclear lamina
GO:0031965--C:nuclear membrane
GO:0005640--C:nuclear outer membrane
GO:0005634--C:nucleus
GO:0003779--F:actin binding
GO:0048487--F:beta-tubulin binding
GO:0071363--P:cellular response to growth factor stimulus
GO:0035414--P:negative regulation of catenin import into nucleus
GO:0048147--P:negative regulation of fibroblast proliferation
GO:0046827--P:positive regulation of protein export from nucleus
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0035914--P:skeletal muscle cell differentiation