| Tag |
Content |
| dbPAF ID |
dbPAF-0000279 |
| Uniprot Accession |
O08575; EYA2_MOUSE; A2A5S4; P97925;
|
| Genbank Protein ID |
NP_001258891.1; NP_001258892.1; NP_034295.1;
|
| Genbank Nucleotide ID |
NM_001271962.1; NM_001271963.1; NM_010165.3;
|
| Protein Name |
Eyes absent homolog 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
Eya2 |
| Gene Synonyms/Alias |
Eab1; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:10490620, PubMed:17098221). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (By similarity).Functional Description
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:10490620, PubMed:17098221). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MLEVVTSPSL ATSSDWSEHG AAVGTLSDRE GIAKSAALSV PQLFVKSHPR VPPGQSSTAM 60
AAYGQTQYST GIQQAPPYTA YPTPAQAYGI PPYSIKTEDS LNHSPSQSGF LSYGPSFSTA 120
PAGQSPYTYP VHSTAGLYQG ANGLTNTAGF GSVHQDYPSY PSFSQNQYPQ YFSPSYNPPY 180
VPASSLCSSP LSTSTYVLQE APHNVPSQSS ESLAGDYNTH NGPSTPAKEG DTERPHRASD 240
GKLRGRSKRN SDPSPAGDNE IERVFVWDLD ETIIIFHSLL TGTFASRYGK DTTTSVRIGL 300
MMEEMIFNLA DTHLFFNDLE DCDQIHVDDV SSDDNGQDLS TYNFSTDGFH STAPGASLCL 360
GTGVHGGVDW MRKLAFRYRR VKEMYNTYRN NVGGLIGAPK RETWLQLRAE LEALTDLWLT 420
HSLKALNLIN SRPNCVNVLV TTTQLIPALA KVLLYGLGSV FPIENIYSAT KTGKESCFER 480
IMQRFGRKAV YIVIGDGVEE EQGAKKHNMP FWRISCHADL EALRHALELE YL
533Fasta Sequence
>O08575|Eya2|Mus musculus(Mouse)
MLEVVTSPSLATSSDWSEHGAAVGTLSDREGIAKSAALSVPQLFVKSHPRVPPGQSSTAMAAYGQTQYSTGIQQAPPYTAYPTPAQAYGIPPYSIKTEDSLNHSPSQSGFLSYGPSFSTAPAGQSPYTYPVHSTAGLYQGANGLTNTAGFGSVHQDYPSYPSFSQNQYPQYFSPSYNPPYVPASSLCSSPLSTSTYVLQEAPHNVPSQSSESLAGDYNTHNGPSTPAKEGDTERPHRASDGKLRGRSKRNSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSTDGFHSTAPGASLCLGTGVHGGVDWMRKLAFRYRRVKEMYNTYRNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL
|
| Keyword |
KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR028473--EYA2
IPR006545--EYA_dom
IPR028472--EYA_fam
IPR023214--HAD-like_dom
|
| PROSITE |
|
| Pfam |
PF00702--Hydrolase
|
| Gene Ontology |
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000287--F:magnesium ion binding
GO:0004725--F:protein tyrosine phosphatase activity
GO:0006281--P:DNA repair
GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand
GO:0016576--P:histone dephosphorylation
GO:0097345--P:mitochondrial outer membrane permeabilization
GO:0007275--P:multicellular organismal development
GO:0035335--P:peptidyl-tyrosine dephosphorylation
GO:0006470--P:protein dephosphorylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0014706--P:striated muscle tissue development
GO:0006351--P:transcription, DNA-templated
|
