dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000278 | ||||||||
| Uniprot Accession | O08574; MESP2_MOUSE; Q3UIV5; | ||||||||
| Genbank Protein ID | NP_032615.2; | ||||||||
| Genbank Nucleotide ID | NM_008589.2; | ||||||||
| Protein Name | Mesoderm posterior protein 2 | ||||||||
| Protein Synonyms/Alias | |||||||||
| Gene Name | Mesp2 | ||||||||
| Gene Synonyms/Alias | |||||||||
| Organism | Mus musculus(Mouse) | ||||||||
| NCBI Taxa ID | 10090 | ||||||||
| Functional Description (View all) |
Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes. Controls also the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1. Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MAQSSPPQSL QGLVPLGLLP GLGLGSAIGL HVSGLVLRFV RFLPFYATRR PSQPAGPARS 60 TRTTQATAPR RTRPAPAGGQ RQSASEREKL RMRTLARALQ ELRRFLPPSV APAGQSLTKI 120 ETLRLAIRYI GHLSALLGLS EDSLRRRRRR SADAAFSHRC PQCPDGGSPS QAQMLGPSLG 180 SAMSSGVSWG CPPACPGPLI SPENLGNRIS NVDPRVTPPY CPQIQSPLHQ SLERAADSSP 240 WAPPQACPGM QMSPEPRNKT GHWTQSTEPA ELTKVYQSLS VSPEPRLSLG SPLLLPRPSC 300 QRLQPQPQPQ PQWGCWGHDA EVLSTSEDQG SSPALQLPVA SPTPSSGLQL SGCPELWQED 360 LEGPPLNIFY 371 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR011598--bHLH_dom |
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| PROSITE | PS50888--BHLH |
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| Pfam | PF00010--HLH |
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| Gene Ontology | GO:0070062--C:extracellular exosome |