| Tag |
Content |
| dbPAF ID |
dbPAF-0000277 |
| Uniprot Accession |
O08573; LEG9_MOUSE; O08572; Q3UKE5; Q99L83;
|
| Genbank Protein ID |
NP_001152773.1; NP_034838.2;
|
| Genbank Nucleotide ID |
NM_001159301.1; NM_010708.2;
|
| Protein Name |
Galectin-9 |
| Protein Synonyms/Alias |
|
| Gene Name |
Lgals9 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (PubMed:20937702). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (PubMed:25065622). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (By similarity). Expands regulatory T cells and induces cytotoxic T cell apoptosis following virus infection (By similarity). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (By similarity). Inhibits degranulation and induces apoptosis of mast cells (By similarity). Induces maturation and migration of dendritic cells (By similarity). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (By similarity). Astrocyte derived galectin-9 enhances microglial TNF production (PubMed:25158758). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity).Functional Description
Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (PubMed:20937702). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (PubMed:25065622). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (By similarity). Expands regulatory T cells and induces cytotoxic T cell apoptosis following virus infection (By similarity). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (By similarity). Inhibits degranulation and induces apoptosis of mast cells (By similarity). Induces maturation and migration of dendritic cells (By similarity). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (By similarity). Astrocyte derived galectin-9 enhances microglial TNF production (PubMed:25158758). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MALFSAQSPY INPIIPFTGP IQGGLQEGLQ VTLQGTTKSF AQRFVVNFQN SFNGNDIAFH 60
FNPRFEEGGY VVCNTKQNGQ WGPEERKMQM PFQKGMPFEL CFLVQRSEFK VMVNKKFFVQ 120
YQHRVPYHLV DTIAVSGCLK LSFITFQNSA APVQHVFSTL QFSQPVQFPR TPKGRKQKTQ 180
NFRPAHQAPM AQTTIHMVHS TPGQMFSTPG IPPVVYPTPA YTIPFYTPIP NGLYPSKSIM 240
ISGNVLPDAT RFHINLRCGG DIAFHLNPRF NENAVVRNTQ INNSWGQEER SLLGRMPFSR 300
GQSFSVWIIC EGHCFKVAVN GQHMCEYYHR LKNLQDINTL EVAGDIQLTH VQT
354Fasta Sequence
>O08573|Lgals9|Mus musculus(Mouse)
MALFSAQSPYINPIIPFTGPIQGGLQEGLQVTLQGTTKSFAQRFVVNFQNSFNGNDIAFHFNPRFEEGGYVVCNTKQNGQWGPEERKMQMPFQKGMPFELCFLVQRSEFKVMVNKKFFVQYQHRVPYHLVDTIAVSGCLKLSFITFQNSAAPVQHVFSTLQFSQPVQFPRTPKGRKQKTQNFRPAHQAPMAQTTIHMVHSTPGQMFSTPGIPPVVYPTPAYTIPFYTPIPNGLYPSKSIMISGNVLPDATRFHINLRCGGDIAFHLNPRFNENAVVRNTQINNSWGQEERSLLGRMPFSRGQSFSVWIICEGHCFKVAVNGQHMCEYYHRLKNLQDINTLEVAGDIQLTHVQT
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0145--Chemotaxis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0430--Lectin
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
|
| Interpro |
IPR013320--ConA-like_dom
IPR001079--Galectin_CRD
|
| PROSITE |
PS51304--GALECTIN
|
| Pfam |
PF00337--Gal-bind_lectin
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005576--C:extracellular region
GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0030246--F:carbohydrate binding
GO:0019899--F:enzyme binding
GO:0016936--F:galactoside binding
GO:0043539--F:protein serine/threonine kinase activator activity
GO:0005102--F:receptor binding
GO:0098586--P:cellular response to virus
GO:0006935--P:chemotaxis
GO:0007565--P:female pregnancy
GO:0007157--P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0002376--P:immune system process
GO:0045185--P:maintenance of protein location
GO:2000562--P:negative regulation of CD4-positive, alpha-beta T cell proliferation
GO:0010629--P:negative regulation of gene expression
GO:0050728--P:negative regulation of inflammatory response
GO:0032689--P:negative regulation of interferon-gamma production
GO:1902714--P:negative regulation of interferon-gamma secretion
GO:0032815--P:negative regulation of natural killer cell activation
GO:0043322--P:negative regulation of natural killer cell degranulation
GO:0032722--P:positive regulation of chemokine production
GO:0001819--P:positive regulation of cytokine production
GO:1900426--P:positive regulation of defense response to bacterium
GO:0010628--P:positive regulation of gene expression
GO:0045089--P:positive regulation of innate immune response
GO:0032732--P:positive regulation of interleukin-1 production
GO:2001181--P:positive regulation of interleukin-10 secretion
GO:2000778--P:positive regulation of interleukin-6 secretion
GO:0043032--P:positive regulation of macrophage activation
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010862--P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0045591--P:positive regulation of regulatory T cell differentiation
GO:2000406--P:positive regulation of T cell migration
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0032823--P:regulation of natural killer cell differentiation
GO:0032496--P:response to lipopolysaccharide
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