| Tag |
Content |
| dbPAF ID |
dbPAF-0000276 |
| Uniprot Accession |
O08565; CXCR4_RAT;
|
| Genbank Protein ID |
|
| Genbank Nucleotide ID |
|
| Protein Name |
C-X-C chemokine receptor type 4 |
| Protein Synonyms/Alias |
|
| Gene Name |
Cxcr4 |
| Gene Synonyms/Alias |
Cmkar4; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).Functional Description
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 345 | STESESSSFHSS--- | curated | 23712012 |
|
Sequence
(Fasta) | MEIYTSDNYS EEVGSGDYDS NKEPCFRDEN ENFNRIFLPT IYFIIFLTGI VGNGLVILVM 60
GYQKKLRSMT DKYRLHLSVA DLLFVITLPF WAVDAMADWY FGKFLCKAVH IIYTVNLYSS 120
VLILAFISLD RYLAIVHATN SQSARKLLAE KAVYVGVWIP ALLLTIPDII FADVSQGDGR 180
YICDRLYPDS LWMVVFQFQH IMVGLILPGI VILSCYCIII SKLSHSKGHQ KRKALKTTVI 240
LILAFFACWL PYYVGISIDS FILLEVIKQG CEFESVVHKW ISITEALAFF HCCLNPILYA 300
FLGAKFKSSA QHALNSMSRG SSLKILSKGK RGGHSSVSTE SESSSFHSS
Fasta Sequence
>O08565|Cxcr4|Rattus norvegicus(Rat)
MEIYTSDNYSEEVGSGDYDSNKEPCFRDENENFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATNSQSARKLLAEKAVYVGVWIPALLLTIPDIIFADVSQGDGRYICDRLYPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLEVIKQGCEFESVVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
|
| Keyword |
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0967--Endosome
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0458--Lysosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0654--Proteoglycan
KW-0675--Receptor
KW-1185--Reference proteome
KW-0765--Sulfation
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
|
| Interpro |
IPR001277--Chemokine_CXCR4
IPR022726--Chemokine_CXCR4_N_dom
IPR000355--Chemokine_rcpt
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
|
| PROSITE |
PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
|
| Pfam |
PF00001--7tm_1
PF12109--CXCR4_N
|
| Gene Ontology |
GO:0030054--C:cell junction
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005886--C:plasma membrane
GO:0016493--F:C-C chemokine receptor activity
GO:0016494--F:C-X-C chemokine receptor activity
GO:0008144--F:drug binding
GO:0060048--P:cardiac muscle contraction
GO:0016477--P:cell migration
GO:0071345--P:cellular response to cytokine stimulus
GO:0070098--P:chemokine-mediated signaling pathway
GO:0006935--P:chemotaxis
GO:0002064--P:epithelial cell development
GO:0001764--P:neuron migration
GO:0008038--P:neuron recognition
GO:0042119--P:neutrophil activation
GO:0051924--P:regulation of calcium ion transport
GO:0050920--P:regulation of chemotaxis
GO:0043067--P:regulation of programmed cell death
GO:0022029--P:telencephalon cell migration
|
