dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000275 | ||||||||||||
| Uniprot Accession | O08564; LPP1_RAT; Q8K594; | ||||||||||||
| Genbank Protein ID | |||||||||||||
| Genbank Nucleotide ID | |||||||||||||
| Protein Name | Lipid phosphate phosphohydrolase 1 | ||||||||||||
| Protein Synonyms/Alias | PAP2-alpha;Phosphatidate phosphohydrolase type 2a;Phosphatidic acid phosphatase 2a;PAP-2a;PAP2a; | ||||||||||||
| Gene Name | Ppap2a | ||||||||||||
| Gene Synonyms/Alias | Lpp1; | ||||||||||||
| Organism | Rattus norvegicus(Rat) | ||||||||||||
| NCBI Taxa ID | 10116 | ||||||||||||
| Functional Description (View all) |
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), diacyl glycerol pyrophosphate (DGPP), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > C-1-P > S-1-P. | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MFDKPRLPYV VLDVICVLLA GLPFIILTSR HTPFQRGVFC TDESIKYPYR EDTIPYALLG 60 GIVIPFCIIV MITGETLSVY FNVLHSNSFV SNHYIATIYK AVGAFLFGAS ASQSLTDIAK 120 YSIGRLRPHF LAVCNPDWSK INCSDGYIEN FVCQGNEQKV REGRLSFYSG HSSFSMYCML 180 FVALYLQARM KGDWARLLRP MLQFGLVALS IYVGLSRVSD YKHHWSDVLI GLIQGAVVAI 240 LVVLYVTDFF KTTESNKERK EDSHTTLHET TNRQSYARNH EP 283 |
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| Keyword | KW-0025--Alternative splicing |
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| Interpro | |||||||||||||
| PROSITE | |||||||||||||
| Pfam | PF01569--PAP2 |
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| Gene Ontology | GO:0005887--C:integral component of plasma membrane |