dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000274 |
| Uniprot Accession | O08562; SCN9A_RAT; |
| Genbank Protein ID | NP_579823.1; |
| Genbank Nucleotide ID | NM_133289.1; |
| Protein Name | Sodium channel protein type 9 subunit alpha |
| Protein Synonyms/Alias | Peripheral sodium channel 1;PN1;Sodium channel protein type IX subunit alpha;Voltage-gated sodium channel subunit alpha Nav1.7; |
| Gene Name | Scn9a |
| Gene Synonyms/Alias | |
| Organism | Rattus norvegicus(Rat) |
| NCBI Taxa ID | 10116 |
| Functional Description (View all) |
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 4 |
| Sequence (Fasta) | MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKEHKDEKK DDEEEGPKPS SDLEAGKQLP 60 FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF NATPALYMLS PFSPLRRISI 120 KILVHSLFSM LIMCTILTNC IFMTLSNPPE WTKNVEYTFT GIYTFESLIK ILARGFCVGE 180 FTFLRDPWNW LDFVVIVFAY LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ 240 SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LKHKCFRKEL EENETLESIM NTAESEEELK 300 KYFYYLEGSK DALLCGFSTD SGQCPEGYIC VKAGRNPDYG YTSFDTFSWA FLALFRLMTQ 360 DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEAKQKE 420 LEFQQMLDRL KKEQEEAEAI AAAAAEFTSI GRSRIMGLSE SSSETSRLSS KSAKERRNRR 480 KKKKQKMSSG EEKGDDEKLS KSGSEESIRK KSFHLGVEGH HRTREKRLST PNQSPLSIRG 540 SLFSARRSSR TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN 600 ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEVIID KATSDDSGTT 660 NQMRKKRLSS SYFLSEDMLN DPHLRQRAMS RASILTNTVE ELEESRQKCP PWWYRFAHTF 720 LIWNCSPYWI KFKKLIYFIV MDPFVDLAIT ICIVLNTLFM AMEHHPMTEE FKNVLAVGNL 780 IFTGIFAAEM VLKLIAMDPY EYFQVGWNIF DSLIVTLSLI ELFLADVEGL SVLRSFRLLR 840 VFKLAKSWPT LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKINV 900 DCKLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVYMMV MVIGNLVVLN 960 LFLALLLSSF SSDNLTAIEE DTDANNLQIA VARIKRGINY VKQTLREFIL KSFSKKPKGS 1020 KDTKRTADPN NKKENYISNR TLAEMSKDHN FLKEKDRISG YGSSLDKSFM DENDYQSFIH 1080 NPSLTVTVPI APGESDLEIM NTEELSSDSD SDYSKEKRNR SSSSECSTVD NPLPGEEEAE 1140 AEPVNADEPE ACFTDGCVRR FPCCQVNVDS GKGKVWWTIR KTCYRIVEHS WFESFIVLMI 1200 LLSSGALAFE DIYIEKKKTI KIILEYADKI FTYIFILEML LKWVAYGYKT YFTNAWCWLD 1260 FLIVDVSLVT LVANTLGYSD LGPIKSLRTL RALRPLRALS RFEGMRVVVN ALIGAIPSIM 1320 NVLLVCLIFW LIFSIMGVNL FAGKFYECVN TTDGSRFPTS QVANRSECFA LMNVSGNVRW 1380 KNLKVNFDNV GLGYLSLLQV ATFKGWMDIM YAAVDSVNVN EQPKYEYSLY MYIYFVIFII 1440 FGSFFTLNLF IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN 1500 KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQTEY MDYVLHWINM VFIILFTGEC 1560 VLKLISLRHY YFTVGWNIFD FVVVILSIVG MFLAEMIEKY FVSPTLFRVI RLARIGRILR 1620 LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG MSNFAYVKKE AGINDMFNFE 1680 TFGNSMICLF QITTSAGWDG LLAPILNSAP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS 1740 YIIISFLVVV NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEFCKL 1800 SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE GGEMDSLRSQ 1860 MEERFMSANP SKVSYEPITT TLKRKQEEVS ATIIQRAYRR YRLRQHVKNI SSIYIKDGDR 1920 DDDLPNKEDT VFDNVNENSS PEKTDVTAST ISPPSYDSVT KPDQEKYETD KTEKEDKEKD 1980 ESRK 1985 |
| Keyword | KW-0181--Complete proteome |
| Interpro | IPR027359--Channel_four-helix_dom |
| PROSITE | |
| Pfam | PF00520--Ion_trans |
| Gene Ontology | GO:0005886--C:plasma membrane |