dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000273
Uniprot Accession O08561; PI4KB_RAT;
Genbank Protein ID NP_112345.1;
Genbank Nucleotide ID NM_031083.1;
Protein Name Phosphatidylinositol 4-kinase beta
Protein Synonyms/Alias
Gene Name Pi4kb
Gene Synonyms/Alias Pik4cb;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
263TLSPAPDTGLSPSKRcurated23984901
275SKRTHQRSKSDATAScurated23984901
277RTHQRSKSDATASIScurated25532521
292LSSNLKRTASNPKVEcurated21630457
294SNLKRTASNPKVENEPhosphoSitePlus;curated22135298; 23712012; 21630457
331PEREFIKSLMAIGKRcurated25532521
425IPENRIRSTRSVENLcurated23984901
428NRIRSTRSVENLPECPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521; 22817900; 21630457; 22276854
511GDIRRRLSEQLAHTPPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521; 23712012; 21630457; 22276854
Sequence
(Fasta)		MGDMVVEPAT LKPTSEPTPS PSGNNGGSLL SVITEGVGEL SVIDPEVAQK ACQEVLEKVK 60
LLHGGVAISS KGSPLELVNG DGVDNEIRCL DDPPTEIREE EDEMEPGVVS GTAKGTRRRR 120
QNNSAKQSWL LRLFESKLFD ISMAISYLYN SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL 180
NMYIHMDEDV GDAIKPYIVH RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI 240
LSDELKPAHR KRELPTLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN 300
EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ RLISELSLLN 360
HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY VEVLECENFD TTNVPARIPE 420
NRIRSTRSVE NLPECGITHE QRAGSFSTVP NYDNDDEAWS VDDIGELQVE LPEVHTNSCD 480
NISQFSVDSI TSQESKEPVF IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK 540
VRRIREGSPY GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI 600
LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ RNFVQSCAGY 660
CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN LGFETSAFKL TTEFVDVMGG 720
LNGDMFNYYK MLMLQGLIAA RKHMDKVVQI VEIMQQGSQL PCFHGSSTIR NLKERFHMSM 780
TEEQLQLLVE QMVDGSMRSI TTKLYDGFQY LTNGIM 817
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0418--Kinase
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR000403--PI3/4_kinase_cat_dom
IPR018936--PI3/4_kinase_CS
IPR015433--PI_Kinase
IPR001263--PInositide-3_kin_accessory_dom
PROSITE

PS00915--PI3_4_KINASE_1
PS00916--PI3_4_KINASE_2
PS50290--PI3_4_KINASE_3
PS51545--PIK_HELICAL
Pfam

PF00454--PI3_PI4_kinase
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005741--C:mitochondrial outer membrane
GO:0005886--C:plasma membrane
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0004430--F:1-phosphatidylinositol 4-kinase activity
GO:0005524--F:ATP binding
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0046854--P:phosphatidylinositol phosphorylation
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0007165--P:signal transduction