| Tag |
Content |
| dbPAF ID |
dbPAF-0000272 |
| Uniprot Accession |
O08560; DGKZ_RAT;
|
| Genbank Protein ID |
NP_112405.1;
|
| Genbank Nucleotide ID |
NM_031143.1;
|
| Protein Name |
Diacylglycerol kinase zeta |
| Protein Synonyms/Alias |
|
| Gene Name |
Dgkz |
| Gene Synonyms/Alias |
Dagk6; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity).Functional Description
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MEPRDPSPEA RSSDSESASA SSSGSERDAD PEPDKAPRRL TKRRFPGLRL FGHRKAITKS 60
GLQHLAPPPP TPGAPCGESE RQIRSTVDWS ESAAYGEHIW FETNVSGDFC YVGEQYCVAK 120
MLPKSAPRRK CAACKIVVHT PCIGQLEKIN FRCKPSFRES GSRNVREPTF VRHHWVHRRR 180
QDGKCRHCGK GFQQKFTFHS KEIVAISCSW CKQAYHSKVS CFMLQQIEEP CSLGVHAAVV 240
IPPTWILRAR RPQNTLKASK KKKRASFKRR SSKKGPEEGR WRPFIIRPTP SPLMKPLLVF 300
VNPKSGGNQG AKIIQSFLWY LNPRQVFDLS QGGPREALEM YRKVHNLRIL ACGGDGTVGW 360
ILSTLDQLRL KPPPPVAILP LGTGNDLART LNWGGGYTDE PVSKILSHVE EGNVVQLDRW 420
DLRAEPNPEA GPEERDDGAT DRLPLDVFNN YFSLGFDAHV TLEFHESREA NPEKFNSRFR 480
NKMFYAGTAF SDFLMGSSKD LAKHIRVVCD GMDLTPKIQD LKPQCIVFLN IPRYCAGTMP 540
WGHPGEHHDF EPQRHDDGYL EVIGFTMTSL AALQVGGHGE RLTQCREVLL TTAKAIPVQV 600
DGEPCKLAAS RIRIALRNQA TMVQKAKRRS TAPLHSDQQP VPEQLRIQVS RVSMHDYEAL 660
HYDKEQLKEA SVPLGTVVVP GDSDLELCRA HIERLQQEPD GAGAKSPMCH PLSSKWCFLD 720
ATTASRFYRI DRAQEHLNYV TEIAQDEIYI LDPELLGASA RPDLPTPTSP LPASPCSPTP 780
GSLQGDAALP QGEELIEAAK RNDFCKLQEL HRAGGDLMHR DHQSRTLLHH AVSTGSKEVV 840
RYLLDHAPPE ILDAVEENGE TCLHQAAALG QRTICHYIVE AGASLMKTDQ QGDTPRQRAE 900
KAQDTELAAY LENRQHYQMI QREDQETAV
Fasta Sequence
>O08560|Dgkz|Rattus norvegicus(Rat)
MEPRDPSPEARSSDSESASASSSGSERDADPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESERQIRSTVDWSESAAYGEHIWFETNVSGDFCYVGEQYCVAKMLPKSAPRRKCAACKIVVHTPCIGQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPMCHPLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSLQGDAALPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDHQSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
|
| Keyword |
KW-0040--ANK repeat
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000756--Diacylglycerol_kin_accessory
IPR001206--Diacylglycerol_kinase_cat_dom
IPR016064--NAD/diacylglycerol_kinase
IPR002219--PE/DAG-bd
|
| PROSITE |
PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50146--DAGK
|
| Pfam |
PF12796--Ank_2
PF00130--C1_1
PF00609--DAGK_acc
PF00781--DAGK_cat
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0030027--C:lamellipodium
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004143--F:diacylglycerol kinase activity
GO:0004857--F:enzyme inhibitor activity
GO:0001727--F:lipid kinase activity
GO:0046872--F:metal ion binding
GO:0035556--P:intracellular signal transduction
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway
|
