dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000271
Uniprot Accession O08557; DDAH1_RAT;
Genbank Protein ID NP_071633.1;
Genbank Nucleotide ID NM_022297.2;
Protein Name N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Protein Synonyms/Alias
Gene Name Ddah1
Gene Synonyms/Alias Ddah;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
33CRHALRRSQGEEVDFPhosphoSitePlus;UniProt;curated22135298; 22673903; 21630457; 23984901
56LYVGVLGSKLGLQVVPhosphoSitePlus;curated22135298; 23984901
Sequence
(Fasta)		MAGLSHPSVF GRATHAVVRA PPESLCRHAL RRSQGEEVDF ARAERQHQLY VGVLGSKLGL 60
QVVQLPADES LPDCVFVEDV AVVCEETALI TRPGAPSRRK EVDMMKEALE KLQLNIVEMK 120
DENATLDGGD VLFTGREFFV GLSKRTNQRG AEILADTFKD YAVSTVPVAD SLHLKSFCSM 180
AGPNLIAIGS SESAQKALKI MQQMSDHRYD KLTVPDDMAA NCIYLNIPSK GHVLLHRTPE 240
EYPESAKVYE KLKDHLLIPV SNSEMEKVDG LLTCCSVFIN KKTDS 286
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0702--S-nitrosylation
KW-0862--Zinc
Interpro

IPR003198--Amidino_trans
PROSITE
Pfam

PF02274--Amidinotransf
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0016597--F:amino acid binding
GO:0016403--F:dimethylargininase activity
GO:0046872--F:metal ion binding
GO:0006525--P:arginine metabolic process
GO:0000052--P:citrulline metabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0045429--P:positive regulation of nitric oxide biosynthetic process
GO:0003073--P:regulation of systemic arterial blood pressure