Tag |
Content |
dbPAF ID |
dbPAF-0000270 |
Uniprot Accession |
O08556; CCR5_RAT;
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Genbank Protein ID |
NP_446412.2;
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Genbank Nucleotide ID |
NM_053960.3;
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Protein Name |
C-C chemokine receptor type 5 |
Protein Synonyms/Alias |
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Gene Name |
Ccr5 |
Gene Synonyms/Alias |
Cmkbr5; |
Organism |
Rattus norvegicus(Rat) |
NCBI Taxa ID |
10116 |
Functional Description (View all) |
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).Functional Description
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).
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Phosphorylation Sites
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dbPAF PTMs: 1 Position | Peptides | Source | References ( PMIDs ) |
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299 | CCLNPVIYAFVGEKF | PhosphoSitePlus | 22135298 |
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Sequence (Fasta) | MDFQGSIPTY IYDIDYSMSA PCQKVNVKQI AAQLLPPLYS LVFIFGFVGN MMVFLILISC 60 KKLKSMTDIY LFNLAISDLL FLLTLPFWAH YAANEWVFGN IMCKLFTGIY HIGYFGGIFF 120 IILLTIDRYL AIVHAVFAIK ARTVNFGVIT SVVTWVVAVF VSLPEIIFMR SQKEGSHYTC 180 SPHFLHIQYR FWKHFQTLKM VILSLILPLL VMVICYSGIL NTLFRCRNEK KRHRAVRLIF 240 AIMIVYFLFW TPYNIVLLLT TFQEYFGLNN CSSSNRLDQA MQVTETLGMT HCCLNPVIYA 300 FVGEKFRNYL SVFFRKHIVK RFCKHCSIFQ QVNPDRVSSV YTRSTGEQEV STGL
355Fasta Sequence
>O08556|Ccr5|Rattus norvegicus(Rat) MDFQGSIPTYIYDIDYSMSAPCQKVNVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKLFTGIYHIGYFGGIFFIILLTIDRYLAIVHAVFAIKARTVNFGVITSVVTWVVAVFVSLPEIIFMRSQKEGSHYTCSPHFLHIQYRFWKHFQTLKMVILSLILPLLVMVICYSGILNTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEYFGLNNCSSSNRLDQAMQVTETLGMTHCCLNPVIYAFVGEKFRNYLSVFFRKHIVKRFCKHCSIFQQVNPDRVSSVYTRSTGEQEVSTGL
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Keyword |
KW-1003--Cell membrane KW-0181--Complete proteome KW-1015--Disulfide bond KW-0297--G-protein coupled receptor KW-0325--Glycoprotein KW-0449--Lipoprotein KW-0472--Membrane KW-0564--Palmitate KW-0597--Phosphoprotein KW-0675--Receptor KW-1185--Reference proteome KW-0765--Sulfation KW-0807--Transducer KW-0812--Transmembrane KW-1133--Transmembrane helix
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Interpro |
IPR002240--Chemokine_CCR5 IPR000355--Chemokine_rcpt IPR000276--GPCR_Rhodpsn IPR017452--GPCR_Rhodpsn_7TM
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PROSITE |
PS00237--G_PROTEIN_RECEP_F1_1 PS50262--G_PROTEIN_RECEP_F1_2
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Pfam |
PF00001--7tm_1
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Gene Ontology |
GO:0009986--C:cell surface GO:0005737--C:cytoplasm GO:0005829--C:cytosol GO:0005768--C:endosome GO:0016021--C:integral component of membrane GO:0005886--C:plasma membrane GO:0016493--F:C-C chemokine receptor activity GO:0071791--F:chemokine (C-C motif) ligand 5 binding GO:0019901--F:protein kinase binding GO:0007568--P:aging GO:0070098--P:chemokine-mediated signaling pathway GO:0006935--P:chemotaxis GO:0042742--P:defense response to bacterium GO:0045444--P:fat cell differentiation GO:0030900--P:forebrain development GO:0006954--P:inflammatory response GO:0002437--P:inflammatory response to antigenic stimulus GO:0050900--P:leukocyte migration GO:0030517--P:negative regulation of axon extension GO:0030336--P:negative regulation of cell migration GO:2000178--P:negative regulation of neural precursor cell proliferation GO:0070997--P:neuron death GO:0060139--P:positive regulation of apoptotic process by virus GO:0090050--P:positive regulation of cell migration involved in sprouting angiogenesis GO:0022409--P:positive regulation of cell-cell adhesion GO:0007204--P:positive regulation of cytosolic calcium ion concentration GO:0031622--P:positive regulation of fever generation GO:0010628--P:positive regulation of gene expression GO:0050729--P:positive regulation of inflammatory response GO:0050718--P:positive regulation of interleukin-1 beta secretion GO:0032755--P:positive regulation of interleukin-6 production GO:0045666--P:positive regulation of neuron differentiation GO:0032760--P:positive regulation of tumor necrosis factor production GO:0010212--P:response to ionizing radiation GO:0032496--P:response to lipopolysaccharide
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