dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000270
Uniprot Accession O08556; CCR5_RAT;
Genbank Protein ID NP_446412.2;
Genbank Nucleotide ID NM_053960.3;
Protein Name C-C chemokine receptor type 5
Protein Synonyms/Alias
Gene Name Ccr5
Gene Synonyms/Alias Cmkbr5;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
299CCLNPVIYAFVGEKFPhosphoSitePlus22135298
Sequence
(Fasta)		MDFQGSIPTY IYDIDYSMSA PCQKVNVKQI AAQLLPPLYS LVFIFGFVGN MMVFLILISC 60
KKLKSMTDIY LFNLAISDLL FLLTLPFWAH YAANEWVFGN IMCKLFTGIY HIGYFGGIFF 120
IILLTIDRYL AIVHAVFAIK ARTVNFGVIT SVVTWVVAVF VSLPEIIFMR SQKEGSHYTC 180
SPHFLHIQYR FWKHFQTLKM VILSLILPLL VMVICYSGIL NTLFRCRNEK KRHRAVRLIF 240
AIMIVYFLFW TPYNIVLLLT TFQEYFGLNN CSSSNRLDQA MQVTETLGMT HCCLNPVIYA 300
FVGEKFRNYL SVFFRKHIVK RFCKHCSIFQ QVNPDRVSSV YTRSTGEQEV STGL 355
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0765--Sulfation
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR002240--Chemokine_CCR5
IPR000355--Chemokine_rcpt
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
PROSITE

PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
Pfam

PF00001--7tm_1
Gene Ontology

GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0016493--F:C-C chemokine receptor activity
GO:0071791--F:chemokine (C-C motif) ligand 5 binding
GO:0019901--F:protein kinase binding
GO:0007568--P:aging
GO:0070098--P:chemokine-mediated signaling pathway
GO:0006935--P:chemotaxis
GO:0042742--P:defense response to bacterium
GO:0045444--P:fat cell differentiation
GO:0030900--P:forebrain development
GO:0006954--P:inflammatory response
GO:0002437--P:inflammatory response to antigenic stimulus
GO:0050900--P:leukocyte migration
GO:0030517--P:negative regulation of axon extension
GO:0030336--P:negative regulation of cell migration
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0070997--P:neuron death
GO:0060139--P:positive regulation of apoptotic process by virus
GO:0090050--P:positive regulation of cell migration involved in sprouting angiogenesis
GO:0022409--P:positive regulation of cell-cell adhesion
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0031622--P:positive regulation of fever generation
GO:0010628--P:positive regulation of gene expression
GO:0050729--P:positive regulation of inflammatory response
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032755--P:positive regulation of interleukin-6 production
GO:0045666--P:positive regulation of neuron differentiation
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0010212--P:response to ionizing radiation
GO:0032496--P:response to lipopolysaccharide