dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000269
Uniprot Accession O08553; DPYL2_MOUSE; Q6P5D0;
Genbank Protein ID NP_034085.2;
Genbank Nucleotide ID NM_009955.3;
Protein Name Dihydropyrimidinase-related protein 2
Protein Synonyms/Alias
Gene Name Dpysl2
Gene Synonyms/Alias Crmp2;Ulip2;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Phosphorylation Sites
 dbPAF PTMs: 36 (View all)
PositionPeptidesSourceReferences ( PMIDs )
13KKNIPRITSDRLLIKPhosphoSitePlus;curated22135298; 25266776; 22817900; 25521595
14KNIPRITSDRLLIKGdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated20415495; 21183079; 16381945; 23193290; 21081558; 22135298;
30KIVNDDQSFYADIYMPhosphoSitePlus22135298
32VNDDQSFYADIYMEDdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated18034455; 19652227; 16381945; 23193290; 15345747; 22135298;
177FKDRFQLTDSQIYEVdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated20415495; 16381945; 23193290; 21081558; 22135298; 22817900
179DRFQLTDSQIYEVLSPHOSIDA;PhosphoSitePlus21081558; 22135298
182QLTDSQIYEVLSVIRPhosphoSitePlus22135298
282YGEPITASLGTDGSHcurated25338131
290LGTDGSHYWSKNWAKPhosphoPep 2.019060867
292TDGSHYWSKNWAKAAcurated21183079
304KAAAFVTSPPLSPDPcurated25338131
308FVTSPPLSPDPTTPDcurated25338131
402YPRKGRISVGSDADLdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated20415495; 21183079; 16381945; 23193290; 21081558; 19060867;
405KGRISVGSDADLVIWdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated20415495; 16381945; 23193290; 21081558; 19060867; 22135298;
427ISAKTHNSALEYNIFPhosphoPep 2.019060867
431THNSALEYNIFEGMEdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18034455; 16381945; 23193290; 18563927; 20415495; 21183079;
442EGMECRGSPLVVISQPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 22817900
458KIVLEDGTLHVTEGSPhosphoSitePlus22135298
462EDGTLHVTEGSGRYIdbPTM 3.0-; 16381945; 23193290
465TLHVTEGSGRYIPRKdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt;curated15648052; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI VPGGVKTIEA 60
HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG TTMIIDHVVP EPGTSLLAAF 120
DQWREWADSK SCCDYSLHVD ITEWHKGIQE EMEALVKDHG VNSFLVYMAF KDRFQLTDSQ 180
IYEVLSVIRD IGAIAQVHAE NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRSI 240
TIANQTNCPL YVTKVMSKSA AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA 300
FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL IPEGTNGTEE 360
RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR ISVGSDADLV IWDPDSVKTI 420
SAKTHNSALE YNIFEGMECR GSPLVVISQG KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK 480
RIKARSRLAE LRGVPRGLYD GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS 540
LSGAQIDDNI PRRTTQRIVA PPGGRANITS LG 573
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0702--S-nitrosylation
Interpro

IPR006680--Amidohydro-rel
IPR030615--DRP2
IPR011778--Hydantoinase/dihydroPyrase
IPR011059--Metal-dep_hydrolase_composite
IPR032466--Metal_Hydrolase
PROSITE
Pfam

PF01979--Amidohydro_1
Gene Ontology

GO:0030424--C:axon
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:0030426--C:growth cone
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005739--C:mitochondrion
GO:0043209--C:myelin sheath
GO:0043025--C:neuronal cell body
GO:0043195--C:terminal bouton
GO:0016810--F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0019901--F:protein kinase binding
GO:0007411--P:axon guidance
GO:0007010--P:cytoskeleton organization
GO:0006897--P:endocytosis
GO:0021772--P:olfactory bulb development
GO:0014049--P:positive regulation of glutamate secretion
GO:0030516--P:regulation of axon extension
GO:0010975--P:regulation of neuron projection development
GO:0001975--P:response to amphetamine
GO:0042220--P:response to cocaine
GO:0042493--P:response to drug
GO:0021510--P:spinal cord development
GO:0048489--P:synaptic vesicle transport