dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000266 | ||||||||
| Uniprot Accession | O08545; EFNA3_MOUSE; O55217; Q08AV0; | ||||||||
| Genbank Protein ID | NP_034238.1; | ||||||||
| Genbank Nucleotide ID | NM_010108.1; | ||||||||
| Protein Name | Ephrin-A3 | ||||||||
| Protein Synonyms/Alias | EHK1 ligand;EHK1-L;EPH-related receptor tyrosine kinase ligand 3;LERK-3; | ||||||||
| Gene Name | Efna3 | ||||||||
| Gene Synonyms/Alias | Epl3;Eplg3;Lerk3; | ||||||||
| Organism | Mus musculus(Mouse) | ||||||||
| NCBI Taxa ID | 10090 | ||||||||
| Functional Description (View all) |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MAAAPLLLLL LLVPVPLLPL LAQGPGGALG NRHAVYWNSS NQHLRREGYT VQVNVNDYLD 60 IYCPHYNSSG PGGGAEQYVL YMVNLSGYRT CNASQGSKRW ECNRQHASHS PIKFSEKFQR 120 YSAFSLGYEF HAGQEYYYIS TPTHNLHWKC LRMKVFVCCA STSHSGEKPV PTLPQFTMGP 180 NVKINVLEDF EGENPQVPKL EKSISGTSPK REHLPLAVGI AFFLMTLLAS 231 |
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| Keyword | KW-1003--Cell membrane |
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| Interpro | IPR008972--Cupredoxin |
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| PROSITE | |||||||||
| Pfam | PF00812--Ephrin |
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| Gene Ontology | GO:0031225--C:anchored component of membrane |