dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000264
Uniprot Accession O08539; BIN1_MOUSE; Q62434;
Genbank Protein ID NP_033798.1; XP_006526056.1;
Genbank Nucleotide ID NM_009668.2; XM_006525993.2;
Protein Name Myc box-dependent-interacting protein 1
Protein Synonyms/Alias Amphiphysin II;Amphiphysin-like protein;Bridging integrator 1;SH3 domain-containing protein 9;
Gene Name Bin1
Gene Synonyms/Alias Amphl;Sh3p9;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
159SARHHYESLQTAKKKcurated25338131
276SLEKQHGSNTFTVKAPhosphoSitePlus22135298
286FTVKAQPSDNAPEKGdbPTM 3.0;PHOSIDA;PhosphoSitePlus;curated16452087; 16381945; 23193290; 21081558; 22135298; 22817900
296APEKGNKSPSPPPDGdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17114649; 17242355; 19367708; 16381945; 23193290; 16452087;
298EKGNKSPSPPPDGSPdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17114649; 17242355; 19367708; 16381945; 23193290; 15345747;
304PSPPPDGSPAATPEIdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17114649; 17242355; 16381945; 23193290; 15345747; 19655815;
308PDGSPAATPEIRVNHdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17242355; 16381945; 23193290; 21183079; 21081558; 19060867;
321NHEPEPASGASPGATcurated25266776; 23684622; 25338131
324PEPASGASPGATIPKdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19367708; 16381945; 23193290; 19655815; 20415495; 20531401;
328SGASPGATIPKSPSQPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25266776; 23684622; 25521595; 24723360
332PGATIPKSPSQLRKGdbPTM 3.0;PhosphoSitePlus;UniProt;curated19131326; 16381945; 23193290; 21659605; 22135298; 25266776;
334ATIPKSPSQLRKGPPPhosphoSitePlus;curated22135298; 25266776; 23984901; 25338131
349VPPPPKHTPSKEMKQPhosphoSitePlus22135298
351PPPKHTPSKEMKQEQdbPTM 3.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18846507; 16381945; 23193290; 21081558; 22135298; 19366988;
Sequence
(Fasta)		MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR 60
LQKDLRTYLA SVKAMHEASK KLSECLQEVY EPEWPGRDEA NKIAENNDLL WMDYHQKLVD 120
QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKPVSLLEK 180
AAPQWCQGKL QAHLVAQTNL LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN 240
TFQSIAGLEE NFHKEMSKLN QNLNDVLVSL EKQHGSNTFT VKAQPSDNAP EKGNKSPSPP 300
PDGSPAATPE IRVNHEPEPA SGASPGATIP KSPSQLRKGP PVPPPPKHTP SKEMKQEQIL 360
SLFDDAFVPE ISVTTPSQFE APGPFSEQAS LLDLDFEPLP PVASPVKAPT PSGQSIPWDL 420
WEPTESQAGI LPSGEPSSAE GSFAVAWPSQ TAEPGPAQPA EASEVVGGAQ EPGETAASEA 480
TSSSLPAVVV ETFSATVNGA VEGSAGTGRL DLPPGFMFKV QAQHDYTATD TDELQLKAGD 540
VVLVIPFQNP EEQDEGWLMG VKESDWNQHK ELEKCRGVFP ENFTERVQ 589
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0254--Endocytosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0043--Tumor suppressor
Interpro

IPR027267--AH/BAR-dom
IPR003005--Amphiphysin
IPR003023--Amphiphysin_2
IPR004148--BAR_dom
IPR001452--SH3_domain
PROSITE

PS51021--BAR
PS50002--SH3
Pfam

PF03114--BAR
PF14604--SH3_9
Gene Ontology

GO:0030424--C:axon
GO:0043194--C:axon initial segment
GO:0005737--C:cytoplasm
GO:0031674--C:I band
GO:0060987--C:lipid tube
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0033268--C:node of Ranvier
GO:0005634--C:nucleus
GO:0030315--C:T-tubule
GO:0030018--C:Z disc
GO:0042802--F:identical protein binding
GO:0070063--F:RNA polymerase binding
GO:0048156--F:tau protein binding
GO:0006897--P:endocytosis
GO:0060988--P:lipid tube assembly
GO:0042692--P:muscle cell differentiation
GO:0043065--P:positive regulation of apoptotic process
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0071156--P:regulation of cell cycle arrest
GO:0030100--P:regulation of endocytosis
GO:0045664--P:regulation of neuron differentiation