dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000263
Uniprot Accession O08537; ESR2_MOUSE; B2RUC6; E9QKX7; O35635; O70519; Q8BG65; Q91Z86;
Genbank Protein ID NP_034287.3; NP_997590.1;
Genbank Nucleotide ID NM_010157.3; NM_207707.1;
Protein Name Estrogen receptor beta
Protein Synonyms/Alias
Gene Name Esr2
Gene Synonyms/Alias Estrb;Nr3a2;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
61MNYSVPSSTGNLEGGdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus10995228; 16381945; 23193290; 16984883; 22135298
75GPVRQTASPNVLWPTdbPTM 3.0;PhosphoSitePlus17962381; 16381945; 23193290; 22135298
87WPTSGHLSPLATHCQdbPTM 3.0;PhosphoSitePlus10230404; 17962381; 16381945; 23193290; 22135298
105LYAEPQKSPWCEARSdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus9058381; 16381945; 23193290; 10230404; 22135298
176CKAFFKRSIQGHNDYPhosphoSitePlus22135298
236VRRQRSASEQVHCLNdbPTM 3.0;PhosphoSitePlus17166829; 16381945; 23193290; 22135298
488CKNVVPVYDLLLEMLdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus9500442; 16381945; 23193290; 22135298
505HTLRGYKSSISGSECPhosphoSitePlus22135298
Sequence
(Fasta)		MEIKNSPSSL TSPASYNCSQ SILPLEHGPI YIPSSYVESR HEYSAMTFYS PAVMNYSVPS 60
STGNLEGGPV RQTASPNVLW PTSGHLSPLA THCQSSLLYA EPQKSPWCEA RSLEHTLPVN 120
RETLKRKLGG SGCASPVTSP SAKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 180
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSASEQVH 240
CLNKAKRTSG HTPRVKELLL NSLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK 300
LADKELVHMI GWAKKIPGFV ELSLLDQVRL LESCWMEVLM VGLMWRSIDH PGKLIFAPDL 360
VLDRDEGKCV EGILEIFDML LATTARFREL KLQHKEYLCV KAMILLNSSM YPLATASQEA 420
ESSRKLTHLL NAVTDALVWV ISKSGISSQQ QSVRLANLLM LLSHVRHISN KGMEHLLSMK 480
CKNVVPVYDL LLEMLNAHTL RGYKSSISGS ECCSTEDSKS KEGSQNLQSQ 531
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0325--Glycoprotein
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR028355--ER-beta/gamma
IPR021064--Estrogen_rcpt_beta_N
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA
PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2
Pfam

PF12497--ERbeta_N
PF00104--Hormone_recep
PF00105--zf-C4
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003677--F:DNA binding
GO:0019899--F:enzyme binding
GO:0030284--F:estrogen receptor activity
GO:0034056--F:estrogen response element binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0060743--P:epithelial cell maturation involved in prostate gland development
GO:0008628--P:hormone-mediated apoptotic signaling pathway
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:0060766--P:negative regulation of androgen receptor signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001764--P:neuron migration
GO:0001541--P:ovarian follicle development
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0060740--P:prostate gland epithelium morphogenesis
GO:0042127--P:regulation of cell proliferation
GO:0006351--P:transcription, DNA-templated
GO:0060065--P:uterus development
GO:0060068--P:vagina development