Tag |
Content |
dbPAF ID |
dbPAF-0000262 |
Uniprot Accession |
O08530; S1PR1_MOUSE; Q9DC35; Q9R235;
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Genbank Protein ID |
NP_031927.2;
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Genbank Nucleotide ID |
NM_007901.5;
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Protein Name |
Sphingosine 1-phosphate receptor 1 |
Protein Synonyms/Alias |
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Gene Name |
S1pr1 |
Gene Synonyms/Alias |
Edg1;Lpb1; |
Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.Functional Description
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
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Phosphorylation Sites
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dbPAF PTMs: 7 |
Sequence (Fasta) | MVSTSIPEVK ALRSSVSDYG NYDIIVRHYN YTGKLNIGAE KDHGIKLTSV VFILICCFII 60 LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR 120 EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNSSRS FLLISACWVI SLILGGLPIM 180 GWNCISSLSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN 240 ISKASRSSEK SLALLKTVII VLSVFIACWA PLFILLLLDV GCKAKTCDIL YKAEYFLVLA 300 VLNSGTNPII YTLTNKEMRR AFIRIVSCCK CPNGDSAGKF KRPIIPGMEF SRSKSDNSSH 360 PQKDDGDNPE TIMSSGNVNS SS
383Fasta Sequence
>O08530|S1pr1|Mus musculus(Mouse) MVSTSIPEVKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIVSCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS
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Keyword |
KW-0007--Acetylation KW-0037--Angiogenesis KW-1003--Cell membrane KW-0145--Chemotaxis KW-0181--Complete proteome KW-1015--Disulfide bond KW-0967--Endosome KW-0297--G-protein coupled receptor KW-0325--Glycoprotein KW-0449--Lipoprotein KW-0472--Membrane KW-0564--Palmitate KW-0597--Phosphoprotein KW-0675--Receptor KW-1185--Reference proteome KW-0807--Transducer KW-0812--Transmembrane KW-1133--Transmembrane helix
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Interpro |
IPR000987--EDG1_rcpt IPR000276--GPCR_Rhodpsn IPR017452--GPCR_Rhodpsn_7TM IPR004061--S1P_rcpt
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PROSITE |
PS00237--G_PROTEIN_RECEP_F1_1 PS50262--G_PROTEIN_RECEP_F1_2
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Pfam |
PF00001--7tm_1
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Gene Ontology |
GO:0005901--C:caveola GO:0005829--C:cytosol GO:0005768--C:endosome GO:0009897--C:external side of plasma membrane GO:0016021--C:integral component of membrane GO:0031226--C:intrinsic component of plasma membrane GO:0001664--F:G-protein coupled receptor binding GO:0046625--F:sphingolipid binding GO:0038036--F:sphingosine-1-phosphate receptor activity GO:0031532--P:actin cytoskeleton reorganization GO:0007193--P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0001525--P:angiogenesis GO:0001955--P:blood vessel maturation GO:0007420--P:brain development GO:0003245--P:cardiac muscle tissue growth involved in heart morphogenesis GO:0016477--P:cell migration GO:0006935--P:chemotaxis GO:0045446--P:endothelial cell differentiation GO:0061384--P:heart trabecula morphogenesis GO:0030032--P:lamellipodium assembly GO:0051497--P:negative regulation of stress fiber assembly GO:0030182--P:neuron differentiation GO:0030335--P:positive regulation of cell migration GO:0008284--P:positive regulation of cell proliferation GO:0051482--P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0043547--P:positive regulation of GTPase activity GO:0050927--P:positive regulation of positive chemotaxis GO:0048661--P:positive regulation of smooth muscle cell proliferation GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0030500--P:regulation of bone mineralization GO:0045124--P:regulation of bone resorption GO:0030155--P:regulation of cell adhesion GO:0003376--P:sphingosine-1-phosphate signaling pathway GO:0072678--P:T cell migration GO:0019226--P:transmission of nerve impulse
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