dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000262
Uniprot Accession O08530; S1PR1_MOUSE; Q9DC35; Q9R235;
Genbank Protein ID NP_031927.2;
Genbank Nucleotide ID NM_007901.5;
Protein Name Sphingosine 1-phosphate receptor 1
Protein Synonyms/Alias
Gene Name S1pr1
Gene Synonyms/Alias Edg1;Lpb1;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
236RTRSRRLTFRKNISKPhosphoSitePlus22135298
351IIPGMEFSRSKSDNSdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated20415495; 21183079; 16381945; 23193290; 21081558; 19060867;
353PGMEFSRSKSDNSSHdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated17242355; 16381945; 23193290; 19060867; 22135298; 22817900;
355MEFSRSKSDNSSHPQdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17242355; 21183079; 16381945; 23193290; 19060867; 22135298;
358SRSKSDNSSHPQKDDdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated21183079; 16381945; 23193290; 19060867; 22135298; 17242355;
359RSKSDNSSHPQKDDGPhosphoPep 2.019060867
382SGNVNSSS-------curated25338131
Sequence
(Fasta)		MVSTSIPEVK ALRSSVSDYG NYDIIVRHYN YTGKLNIGAE KDHGIKLTSV VFILICCFII 60
LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA NLLLSGATTY KLTPAQWFLR 120
EGSMFVALSA SVFSLLAIAI ERYITMLKMK LHNGSNSSRS FLLISACWVI SLILGGLPIM 180
GWNCISSLSS CSTVLPLYHK HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN 240
ISKASRSSEK SLALLKTVII VLSVFIACWA PLFILLLLDV GCKAKTCDIL YKAEYFLVLA 300
VLNSGTNPII YTLTNKEMRR AFIRIVSCCK CPNGDSAGKF KRPIIPGMEF SRSKSDNSSH 360
PQKDDGDNPE TIMSSGNVNS SS 383
Keyword

KW-0007--Acetylation
KW-0037--Angiogenesis
KW-1003--Cell membrane
KW-0145--Chemotaxis
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0967--Endosome
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000987--EDG1_rcpt
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
IPR004061--S1P_rcpt
PROSITE

PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
Pfam

PF00001--7tm_1
Gene Ontology

GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0009897--C:external side of plasma membrane
GO:0016021--C:integral component of membrane
GO:0031226--C:intrinsic component of plasma membrane
GO:0001664--F:G-protein coupled receptor binding
GO:0046625--F:sphingolipid binding
GO:0038036--F:sphingosine-1-phosphate receptor activity
GO:0031532--P:actin cytoskeleton reorganization
GO:0007193--P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0001525--P:angiogenesis
GO:0001955--P:blood vessel maturation
GO:0007420--P:brain development
GO:0003245--P:cardiac muscle tissue growth involved in heart morphogenesis
GO:0016477--P:cell migration
GO:0006935--P:chemotaxis
GO:0045446--P:endothelial cell differentiation
GO:0061384--P:heart trabecula morphogenesis
GO:0030032--P:lamellipodium assembly
GO:0051497--P:negative regulation of stress fiber assembly
GO:0030182--P:neuron differentiation
GO:0030335--P:positive regulation of cell migration
GO:0008284--P:positive regulation of cell proliferation
GO:0051482--P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0043547--P:positive regulation of GTPase activity
GO:0050927--P:positive regulation of positive chemotaxis
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030500--P:regulation of bone mineralization
GO:0045124--P:regulation of bone resorption
GO:0030155--P:regulation of cell adhesion
GO:0003376--P:sphingosine-1-phosphate signaling pathway
GO:0072678--P:T cell migration
GO:0019226--P:transmission of nerve impulse