| Tag |
Content |
| dbPAF ID |
dbPAF-0000261 |
| Uniprot Accession |
O08529; CAN2_MOUSE; O35518; O54843;
|
| Genbank Protein ID |
NP_033924.2;
|
| Genbank Nucleotide ID |
NM_009794.3;
|
| Protein Name |
Calpain-2 catalytic subunit |
| Protein Synonyms/Alias |
80 kDa M-calpain subunit;CALP80;Calcium-activated neutral proteinase 2;CANP 2;Calpain M-type;Calpain-2 large subunit;Millimolar-calpain;M-calpain; |
| Gene Name |
Capn2 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity).Functional Description
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MAGIAIKLAK DREAAEGLGS HERAIKYLNQ DYETLRNECL EAGALFQDPS FPALPSSLGY 60
KELGPYSSKT RGIEWKRPTE ICADPQFIIG GATRTDICQG ALGDCWLLAA IASLTLNEEI 120
LARVVPPDQS FQENYAGIFH FQFWQYGEWV EVVVDDRLPT KDGELLFVHS AEGSEFWSAL 180
LEKAYAKING CYEALSGGAT TEGFEDFTGG IAEWYELRKP PPNLFKIIQK ALEKGSLLGC 240
SIDITSAADS EAVTYQKLVK GHAYSVTGAE EVESSGSLQK LIRIRNPWGQ VEWTGKWNDN 300
CPSWNTVDPE VRANLTERQE DGEFWMSFSD FLRHYSRLEI CNLTPDTLTC DSYKKWKLTK 360
MDGNWRRGST AGGCRNYPNT FWMNPQYLIK LEEEDEDEED GERGCTFLVG LIQKHRRRQR 420
KMGEDMHTIG FGIYEVPEEL TGQTNIHLGK NFFLTTRARE RSDTFINLRE VLNRFKLPPG 480
EYVLVPSTFE PHKDGDFCIR VFSEKKADYQ AVDDEIEANI EEIDANEEDI DDGFRRLFVQ 540
LAGEDAEISA FELQTILRRV LAKRQDIKSD GFSIETCKIM VDMLDEDGSG KLGLKEFYIL 600
WTKIQKYQKI YREIDVDRSG TMNSYEMRKA LEEAGFKLPC QLHQVIVARF ADDELIIDFD 660
NFVRCLVRLE TLFKIFKQLD PENTGTIQLN LASWLSFSVL
701Fasta Sequence
>O08529|Capn2|Mus musculus(Mouse)
MAGIAIKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQDPSFPALPSSLGYKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPPDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKPPPNLFKIIQKALEKGSLLGCSIDITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLIRIRNPWGQVEWTGKWNDNCPSWNTVDPEVRANLTERQEDGEFWMSFSDFLRHYSRLEICNLTPDTLTCDSYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLGKNFFLTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKDGDFCIRVFSEKKADYQAVDDEIEANIEEIDANEEDIDDGFRRLFVQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDELIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIQLNLASWLSFSVL
|
| Keyword |
KW-0007--Acetylation
KW-0106--Calcium
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
|
| Interpro |
IPR022684--Calpain_cysteine_protease
IPR022682--Calpain_domain_III
IPR022683--Calpain_III
IPR029539--CAPN2
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000169--Pept_cys_AS
IPR001300--Peptidase_C2_calpain_cat
|
| PROSITE |
PS50203--CALPAIN_CAT
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS00139--THIOL_PROTEASE_CYS
|
| Pfam |
PF01067--Calpain_III
PF00648--Peptidase_C2
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005764--C:lysosome
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0097038--C:perinuclear endoplasmic reticulum
GO:0005886--C:plasma membrane
GO:0031143--C:pseudopodium
GO:0005509--F:calcium ion binding
GO:0004198--F:calcium-dependent cysteine-type endopeptidase activity
GO:0008233--F:peptidase activity
GO:0001824--P:blastocyst development
GO:0071230--P:cellular response to amino acid stimulus
GO:0007520--P:myoblast fusion
GO:0016540--P:protein autoprocessing
GO:0006508--P:proteolysis
GO:0051493--P:regulation of cytoskeleton organization
GO:0001666--P:response to hypoxia
|
