| Tag |
Content |
| dbPAF ID |
dbPAF-0000260 |
| Uniprot Accession |
O08528; HXK2_MOUSE;
|
| Genbank Protein ID |
NP_038848.1;
|
| Genbank Nucleotide ID |
NM_013820.3;
|
| Protein Name |
Hexokinase-2 |
| Protein Synonyms/Alias |
Hexokinase type II;HK II; |
| Gene Name |
Hk2 |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
|
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MIASHMIACL FTELNQNQVQ KVDQYLYHMR LSDETLLEIS RRFRKEMEKG LGATTHPTAA 60
VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLRVRVTDN GLQRVEMENQ IYAIPEDIMR 120
GSGTQLFDHI AECLANFMDK LQIKEKKLPL GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV 180
EGRDVVDLIR KAIQRRGDFD IDIVAVVNDT VGTMMTCGYD DQNCEIGLIV GTGSNACYME 240
EMRHIDMVEG DEGRMCINME WGAFGDDGTL NDIRTEFDRE IDMGSLNPGK QLFEKMISGM 300
YMGELVRLIL VKMAKAELLF QGKLSPELLT TGSFETKDVS DIEDDKDGIQ KAYQILVRLG 360
LSPLQEDCVA THRICQIVST RSASLCAATL AAVLWRIKEN KGEERLRSTI GVDGSVYKKH 420
PHFAKRLHKA VRRLVPDCDV RFLRSEDGSG KGAAMVTAVA YRLADQHRAR QKTLESLKLS 480
HEQLLEVKRR MKVEMEQGLS KETHEAAPVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV 540
LLVRVRNGKR RGVEMHNKIY SIPQEVMHGT GEELFDHIVQ CIADFLEYMG MKGVSLPLGF 600
TFSFPCQQNS LDQSILLKWT KGFKASGCEG EDVVTLLKEA IRRREEFDLD VVAVVNDTVG 660
TMMTCGYEDP HCEVGLIVGT GSNACYMEEM RNVELVDGEE GRMCVNMEWG AFGDNGCLDD 720
LRTVFDVAVD ELSLNPGKQR FEKMISGMYL GEIVRNILID FTKRGLLFRG RISERLKTRG 780
IFETKFLSQI ESDCLALLQV RAILRHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA 840
VVDKIRENRG LDNLKVTVGV DGTLYKLHPH FAKVMHETVR DLAPKCDVSF LESEDGSGKG 900
AALITAVACR IREAGQR
918Fasta Sequence
>O08528|Hk2|Mus musculus(Mouse)
MIASHMIACLFTELNQNQVQKVDQYLYHMRLSDETLLEISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVSDIEDDKDGIQKAYQILVRLGLSPLQEDCVATHRICQIVSTRSASLCAATLAAVLWRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLESLKLSHEQLLEVKRRMKVEMEQGLSKETHEAAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIRRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLDDLRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDKIRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR
|
| Keyword |
KW-0007--Acetylation
KW-0021--Allosteric enzyme
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0324--Glycolysis
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
|
| Interpro |
IPR001312--Hexokinase
IPR019807--Hexokinase_BS
IPR022673--Hexokinase_C
IPR022672--Hexokinase_N
|
| PROSITE |
PS00378--HEXOKINASE_1
PS51748--HEXOKINASE_2
|
| Pfam |
PF00349--Hexokinase_1
PF03727--Hexokinase_2
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0005524--F:ATP binding
GO:0008865--F:fructokinase activity
GO:0004340--F:glucokinase activity
GO:0005536--F:glucose binding
GO:0004396--F:hexokinase activity
GO:0019158--F:mannokinase activity
GO:0008637--P:apoptotic mitochondrial changes
GO:0046835--P:carbohydrate phosphorylation
GO:0001678--P:cellular glucose homeostasis
GO:0072655--P:establishment of protein localization to mitochondrion
GO:0051156--P:glucose 6-phosphate metabolic process
GO:0006006--P:glucose metabolic process
GO:0006096--P:glycolytic process
GO:0007595--P:lactation
GO:0072656--P:maintenance of protein location in mitochondrion
GO:0035795--P:negative regulation of mitochondrial membrane permeability
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:1903599--P:positive regulation of mitophagy
GO:0046324--P:regulation of glucose import
GO:0002931--P:response to ischemia
|
