dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000259
Uniprot Accession O02649; CH60_DROME; A4V4A0; P35380; Q6NR71; Q95026; Q9VZ31;
Genbank Protein ID NP_511115.2; NP_727489.1;
Genbank Nucleotide ID NM_078560.3; NM_167266.1;
Protein Name 60 kDa heat shock protein, mitochondrial
Protein Synonyms/Alias 60 kDa chaperonin;CPN60;Heat shock protein 60;HSP-60;Hsp60;Mitochondrial matrix protein P1;
Gene Name Hsp60
Gene Synonyms/Alias Mmp-P1;CG12101;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)		 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
66IIEQSWGSPKITKDGPHOSIDA;PhosphoPep 2.0;curated21081558; 19060867; 22817900
228SPYFINSSKGAKVEFPhosphoPep 2.019060867
395ERLARLASGVALLRVPhosphoPep 2.0;curated19060867; 22817900
Sequence
(Fasta)		MFRLPVSLAR SSISRQLAMR GYAKDVRFGP EVRAMMLQGV DVLADAVAVT MGPKGRNVII 60
EQSWGSPKIT KDGVTVAKSI ELKDKFQNIG AKLVQDVANN TNEEAGDGTT TATVLARAIA 120
KEGFEKISKG ANPVEIRRGV MLAVETVKDN LKTMSRPVST PEEIAQVATI SANGDQAIGN 180
LISEAMKKVG RDGVITVKDG KTLTDELEVI EGMKFDRGYI SPYFINSSKG AKVEFQDALL 240
LLSEKKISSV QSIIPALELA NAQRKPLVII AEDIDGEALS TLVVNRLKIG LQVAAVKAPG 300
FGDNRKSTLT DMAIASGGIV FGDDADLVKL EDVKVSDLGQ VGEVVITKDD TLLLKGKGKK 360
DDVLRRANQI KDQIEDTTSE YEKEKLQERL ARLASGVALL RVGGSSEVEV NEKKDRVHDA 420
LNATRAAVEE GIVPGGGTAL LRCIEKLEGV ETTNEDQKLG VEIVRRALRM PCMTIAKNAG 480
VDGAMVVAKV ENQAGDYGYD ALKGEYGNLI EKGIIDPTKV VRTAITDASG VASLLTTAEA 540
VVTEIPKEDG APAMPGMGGM GGMGGMGGMG GMM 574
Keyword

KW-0067--ATP-binding
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0809--Transit peptide
Interpro

IPR018370--Chaperonin_Cpn60_CS
IPR001844--Chaprnin_Cpn60
IPR002423--Cpn60/TCP-1
IPR027409--GroEL-like_apical_dom
IPR027413--GROEL-like_equatorial
PROSITE

PS00296--CHAPERONINS_CPN60
Pfam

PF00118--Cpn60_TCP1
Gene Ontology

GO:0005811--C:lipid particle
GO:0005875--C:microtubule associated complex
GO:0005743--C:mitochondrial inner membrane
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0005524--F:ATP binding
GO:0034605--P:cellular response to heat
GO:0007005--P:mitochondrion organization
GO:0042026--P:protein refolding