dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0000256 | ||||||||
| Uniprot Accession | O02626; MADD_CAEEL; Q27467; Q8MQF4; | ||||||||
| Genbank Protein ID | NP_001024342.1; NP_741710.1; | ||||||||
| Genbank Nucleotide ID | NM_001029171.3; NM_171618.3; | ||||||||
| Protein Name | MAP kinase-activating death domain protein | ||||||||
| Protein Synonyms/Alias | Aboc, expulsion defective protein 3;Regulator of presynaptic activity aex-3; | ||||||||
| Gene Name | aex-3 | ||||||||
| Gene Synonyms/Alias | C02H7.3; | ||||||||
| Organism | Caenorhabditis elegans | ||||||||
| NCBI Taxa ID | 6239 | ||||||||
| Functional Description (View all) |
Plays a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Novel regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. Is also a regulator of the cab-1 synaptic transmission pathway. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MNDKEKEICP RLIDFLVVVG KRNRTRGASQ SSPDATTDTT VTYPEILRRY PTDDHKDFIL 60 PTDVTVFCQP EGCTTTSARL RKNARNDPQF FVFMLTEKDS AKVRYGICLN FYQSFDRRST 120 PKDEIKKVPD DAHHKKRDSH VSLTSLCFIS HHPFVSIFHQ VLLLLKRIID SSNHRAAQRT 180 GLKDVVWAIL TGHYNEPIVP EVMKEIKEIE TWILMLLSSP VPVPGKTKVQ IEVMPMDLSQ 240 VFEFALPDHT RFTLIDFPLH IPFEILGIDM ALRVLTAAML EFKIVIQSRN YNAVSMCILS 300 IVALLYPLEY MFPVIPLLPA YMPSAEQLLL APTPFLIGVP SSFFHHRKIR ELPSDVILVD 360 LDTNCLQVPD DLYIPDLPEP DATHLKERLK NAINKMTTMT VDNETSVTDA DFGIDIDSVD 420 VACRVAMVQF FNSANVFGNF SEHTRTLRLY PRPVVSLQTD SFLRSRPQCT QLITDLCRTQ 480 AVEYFAECCL CPKNETFVRV QAGIESAEQV GDKPKWFSES LMPVHFMVYP NNSTLDSAIR 540 VYNAEIDNDD YEDDSATSTE NSNSIDDLVF DENQVTDAGG EVTKPLAEVN YIYKEPMTLE 600 LPQSESVVSI DSSLSSGRSS PDSSLSTSAV DSEADFARLA DNLALKSNSQ GAFSFDHGSD 660 SEYESTPVSQ RRKTIHNPGS DASDTPTSRG SIKSGLRMKG LTTLTDSGEK VLGPSLMNAI 720 NGYAEKSQSV FSQVINKTAP KAQALKERTM KPLANRIEQS QHIVRSKTQP NPTSQQTANQ 780 QSKNQQTVKE FCDQALVGQS VGMFSAPKLK RLMEDESLRE LVCSKLNLGL EVKLSEDEYV 840 KEVQLTKGQF KAYVKILKAC LEGIEVSFNT PGCCGFASVF HVLEIAHTHY WAMGGGEVIT 900 PSSSAPSTMT TPSEHSNDIL KESRPKLPAS TIDLRTPTKP LGQNVTPTST NNHEIAQSTR 960 SPALPPPVPP REAPPIPKRN PPPLGAPPKV PEGARAPPPL PPRPKVKTTA VDETPQNLVP 1020 NNQPAQPSSP SFLADADEQT KPLLKPAPPT TLPVGKQEPC KVLPTPNEPV RHYIYQELIL 1080 AVQHQIWQNL QFWENAFVDL VAQEREIVGM DQEPSEMIDR YSALNDSEKK RLELEEDRLL 1140 STLLHNMTAY MIMCGTGQKA LQQKVRRLLG KAHIGLVCSK EINKLLDELP STQGNFIPLK 1200 PLGSRLVQKQ SFTVCPGQSS DGQMMFMEVC DDAVVLRSIT GAATERWWYE RLVNITYSPK 1260 TKILCLWRRH DDKVHMHKFH TKKCRELYQC MKAAMERAAA RGKVNVEGRA LGGEFPVHDT 1320 ETNQGGLLQV RCDGVAVIFA HNQIFIGLSN IKKCNTFGGN VFLLEEFDRK KGEIIQRRYF 1380 SQMADQICYA VLCVFSLAAA GHKKEEHSK |
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| Keyword | KW-0025--Alternative splicing |
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| Interpro | |||||||||
| PROSITE | |||||||||
| Pfam | |||||||||
| Gene Ontology | GO:0005623--C:cell |