dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000251
Uniprot Accession O02365; IFA2_CAEEL;
Genbank Protein ID NP_510648.1;
Genbank Nucleotide ID NM_078247.7;
Protein Name Intermediate filament protein ifa-2
Protein Synonyms/Alias Cel IF A2;Intermediate filament protein A2;IF-A2;
Gene Name ifa-2
Gene Synonyms/Alias mua-6;W10G6.3;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)		 Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle-cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
9TDPDSYRSSITSRPSdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
12DSYRSSITSRPSFNRcurated18806794
13SYRSSITSRPSFNRTcurated18806794
16SSITSRPSFNRTVTSdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
23SFNRTVTSSSQNYGAPhosphoPep 2.019060867
25NRTVTSSSQNYGAPGdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
33QNYGAPGSGNRVLKIdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
42NRVLKIVTETHSSSVcurated18806794
44VLKIVTETHSSSVSSdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
50ETHSSSVSSGLSPYGcurated18806794
51THSSSVSSGLSPYGQdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
54SSVSSGLSPYGQNAAdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
436LVEKVVRTSAINEEAdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
437VEKVVRTSAINEEADdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
Sequence
(Fasta)		MTDPDSYRSS ITSRPSFNRT VTSSSQNYGA PGSGNRVLKI VTETHSSSVS SGLSPYGQNA 60
ASTIRDNRER EKKEIMELND RLASYIEKVR FLDAQNRKLD ADLKMLQGRF GKSTGSVKVM 120
YEMEITTATN VVKQTGKDHG ETEKEIRKLQ DQLDELRKKF EEAQRGRAED RLKIDDLLVT 180
LSNLEAEINL LKRRIALLEE EVARLKKENF RLTSELQRVR IELDQETLLR IDNQNKVKTI 240
LEEIDFMKRG FETELKELQA QAARDTTSEN REYFKNELAN AMRDIRAEYD QIMNGNRNDM 300
ESWYQLRVQE INTQSNRQNA ENNYQKEEVK RLRNQTSELR QKLSDLESRN LLLEKQIEDL 360
NYQLEDDQRS YEAALNDKDA QIRKLREECQ ALMVELQMLL DTKQTLDGEL KVYRQMLEGN 420
SEGNGLRQLV EKVVRTSAIN EEADTETMRV VKGEHSSRTS YQRSAKGNVA IKETSPEGKF 480
VILENTHRAK EEPLGDWKLK RKIDGKREIV FTFPSDYILH PFQSVKIFAR GQGIANPPEV 540
LIFEGDETFG VGANVQTILY NNKGEERATH IQRQSQQTTS S 582
Keyword

KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0403--Intermediate filament
KW-1185--Reference proteome
Interpro

IPR001664--IF
IPR016451--Intermed_filament_ifa/ifb
IPR001322--Lamin_tail_dom
PROSITE
Pfam

PF00038--Filament
Gene Ontology

GO:0030056--C:hemidesmosome
GO:0005882--C:intermediate filament
GO:0005198--F:structural molecule activity
GO:0016337--P:single organismal cell-cell adhesion