dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000248
Uniprot Accession O02328; EIF3C_CAEEL;
Genbank Protein ID NP_492638.1;
Genbank Nucleotide ID NM_060237.3;
Protein Name Eukaryotic translation initiation factor 3 subunit C
Protein Synonyms/Alias
Gene Name eif-3.C
Gene Synonyms/Alias T23D8.4;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)		 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
16EDSDSDTSSSEDEVEPhosphoPep 2.019060867
17DSDSDTSSSEDEVEDPhosphoPep 2.019060867
18SDSDTSSSEDEVEDQPhosphoPep 2.019060867
176PDEDGYETPEDEDDDdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
189DDDFGEVSESKAEKSPhosphoPep 2.019060867
196SESKAEKSPGKPSEKdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
201EKSPGKPSEKAAVSDdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
319MSARGKRTTDRNQHVcurated18806794
Sequence
(Fasta)		MSRFFHAKED SDSDTSSSED EVEDQKVNKS AKFRDDLDFM AGPEEDEKRV VRAQKDKKFD 60
ELKGIIKQNR DAKSNKDLNR LLTGFDSLAK AYDKSKTVFQ RQNVANPRFY IRSLVEIEDY 120
VNKLWDDKDA KSALSKNNAK ALPPLRQKLK KYIKDQQLQD LVTDYRVNPD EDGYETPEDE 180
DDDDFGEVSE SKAEKSPGKP SEKAAVSDSD SDSDDDDSSN WSSEPESNSS DDEDSVTKME 240
QLRRYFLKKE FRVESKDDKK EKKKRVIRVK EAVEEDDDAD WTPVNREKSV VHFDPKEEVT 300
HDVMIKKLNE VMSARGKRTT DRNQHVANLR KLLEVSEEKE LGLGINVKIS FCIISALFEL 360
NAKISDHMEY ETFMTTLQTV NSLLDLLIGT DRVKLSVTYA EEDENLKDDT QEYRIQGSIL 420
IAVQRLDGEL AKILQNADCH SNDYIEKLKA EKDMCSLIEK AEKYVELRND SGIFDKHEVC 480
KVYMMRIEHA YYKYQDQNEE DAGKLMDYLC NKIYTLDDEK RLRQRAMLCH VYYLAVHDKW 540
HRARDLLLMS HMQAIVDHSD VDTQILYNRT ICQLGLCAFR HGFIREAHQG LSEIQNTQRA 600
KELLAQAVGT RQHEKTAEQE KIDRSRQVPY HMHINVELME CVYLICSMLL EIPHMASCEF 660
EMRRRMLSRS FHYQLKQSEK ASLTGPPENT REHVVAASKA MLNGDWKKCQ DYIVNDKMNQ 720
KVWNLFHNAE TVKGMVVRRI QEESLRTYLL TYSTVYATVS LKKLADLFEL SKKDVHSIIS 780
KMIIQEELSA TLDEPTDCLI MHRVEPSRLQ MLALNLSDKL QTLAENNEQI LEPRTGRGGY 840
QGPGSWFPGR NERQGDKQKG SGGYQGERRG GQGQDGKRGN WGSQGGQQRR HPQKPRAF 899
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
Interpro

IPR027516--EIF3C
IPR008905--EIF3C_N_dom
IPR000717--PCI_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE
Pfam

PF05470--eIF-3c_N
PF01399--PCI
Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0003743--F:translation initiation factor activity
GO:0031369--F:translation initiation factor binding
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation
GO:0006413--P:translational initiation