dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000247
Uniprot Accession O02326; CFI1_CAEEL; Q8T628;
Genbank Protein ID NP_492644.2;
Genbank Nucleotide ID NM_060243.2;
Protein Name AT-rich interactive domain-containing protein cfi-1
Protein Synonyms/Alias ARID domain-containing protein CFI-1;
Gene Name cfi-1
Gene Synonyms/Alias T23D8.8;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)
Transcription factor which regulates neuronal subtype identity. Promotes differentiation of URA sensory neurons and prevents them to express male-specific CEM features. Promotes differentiation of AVD and PVC interneurons and their glutamate receptor expression.
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
44DERVDDQTEEQKSPPdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
49DQTEEQKSPPASPDLdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
53EQKSPPASPDLTANLdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
Sequence
(Fasta)
MSVRIDEPQL FVSMSKEPTQ ETVNVGGHHD DSSSNCDERV DDQTEEQKSP PASPDLTANL 60
NVFDLESRQK VVQRLLNSQL NLSNLRAPLN LPPIFQALQG PFSIQQQLLG LASGLTAISP 120
GLDDYDEENT NQGEPEDLTL GGFRKETSVK SEEPSESGIN ASGPAWSYEE QFKQLYELSD 180
DVKRKEWLDD WLNFMHRIGK PVTRIPIMAK QVLDLYELYR LVVQHGGLVE IINKKLWREI 240
TKGLNLPSSI TSAAFTLRTQ YQKYLYDYEC EKEKLSNQSD LQQAIDGNRR EAPGRRTAPS 300
FPLPFQLPHA ASAAATMLNN QLNGLGMRND LLDDENTLSL QASGLFGTSY GAEQMAILEA 360
HQRNLERAQR AVQQQVARQS LGLTACSNGN GGNIHNSGRE STSSNDSDIP AKRPKLENDV 420
KTNGASSMRI STKHSDNSKT SMSVSMEING ITYQGVLFAL DETVSES 468
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR001606--ARID_dom
IPR023334--REKLES_domain

PROSITE

PS51011--ARID
PS51486--REKLES

Pfam

PF01388--ARID

Gene Ontology

GO:0005634--C:nucleus
GO:0043565--F:sequence-specific DNA binding
GO:0045165--P:cell fate commitment
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030182--P:neuron differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated