| Tag |
Content |
| dbPAF ID |
dbPAF-0000238 |
| Uniprot Accession |
O02194; PSN_DROME; O02395; O76802; O96340; Q9TY80; Q9V3L9; Q9V3S1;
|
| Genbank Protein ID |
NP_001262110.1; NP_001262111.1; NP_524184.1; NP_730535.1;
|
| Genbank Nucleotide ID |
NM_001275181.1; NM_001275182.1; NM_079460.2; NM_168856.3;
|
| Protein Name |
Presenilin homolog |
| Protein Synonyms/Alias |
|
| Gene Name |
Psn |
| Gene Synonyms/Alias |
PS;CG18803; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes.Functional Description
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 360 | SPEAAAASGQRTGNS | curated | 22817900 |
|
Sequence
(Fasta) | MAAVNLQASC SSGLASEDDA NVGSQIGAAE RLERPPRRQQ QRNNYGSSNQ DQPDAAILAV 60
PNVVMREPCG SRPSRLTGGG GGSGGPPTNE MEEEQGLKYG AQHVIKLFVP VSLCMLVVVA 120
TINSISFYNS TDVYLLYTPF HEQSPEPSVK FWSALANSLI LMSVVVVMTF LLIVLYKKRC 180
YRIIHGWLIL SSFMLLFIFT YLYLEELLRA YNIPMDYPTA LLIMWNFGVV GMMSIHWQGP 240
LRLQQGYLIF VAALMALVFI KYLPEWTAWA VLAAISIWDL IAVLSPRGPL RILVETAQER 300
NEQIFPALIY SSTVVYALVN TVTPQQSQAT ASSSPSSSNS TTTTRATQNS LASPEAAAAS 360
GQRTGNSHPR QNQRDDGSVL ATEGMPLVTF KSNLRGNAEA AGFTQEWSAN LSERVARRQI 420
EVQSTQSGNA QRSNEYRTVT APDQNHPDGQ EERGIKLGLG DFIFYSVLVG KASSYGDWTT 480
TIACFVAILI GLCLTLLLLA IWRKALPALP ISITFGLIFC FATSAVVKPF MEDLSAKQVF 540
I
542Fasta Sequence
>O02194|Psn|Drosophila melanogaster(Fruit fly)
MAAVNLQASCSSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMEDLSAKQVFI
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP
|
| PROSITE |
|
| Pfam |
PF01080--Presenilin
|
| Gene Ontology |
GO:0016324--C:apical plasma membrane
GO:0030424--C:axon
GO:0005938--C:cell cortex
GO:0009986--C:cell surface
GO:0035253--C:ciliary rootlet
GO:0005737--C:cytoplasm
GO:0043198--C:dendritic shaft
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0000139--C:Golgi membrane
GO:0030426--C:growth cone
GO:0005887--C:integral component of plasma membrane
GO:0005770--C:late endosome
GO:0005765--C:lysosomal membrane
GO:0045121--C:membrane raft
GO:0005743--C:mitochondrial inner membrane
GO:0031594--C:neuromuscular junction
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0055037--C:recycling endosome
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042803--F:protein homodimerization activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0006915--P:apoptotic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0015677--P:copper ion import
GO:0007010--P:cytoskeleton organization
GO:0046331--P:lateral inhibition
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0048812--P:neuron projection morphogenesis
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0002027--P:regulation of heart rate
GO:0008593--P:regulation of Notch signaling pathway
GO:0016337--P:single organismal cell-cell adhesion
GO:0048190--P:wing disc dorsal/ventral pattern formation
|
