| Tag |
Content |
| dbPAF ID |
dbPAF-0000237 |
| Uniprot Accession |
O02193; MOF_DROME; A8B845; A8B850; A8B854; A8B859; A8B879; A8B889; A8B895; A8B8A1; A8ILB7; A8ILC1; A8ILC8; A8ILD1; A8ILD6; A8ILE1; A8ILE5; Q9W463;
|
| Genbank Protein ID |
NP_511051.1;
|
| Genbank Nucleotide ID |
NM_078496.3;
|
| Protein Name |
Males-absent on the first protein |
| Protein Synonyms/Alias |
Histone acetyl transferase MOF; |
| Gene Name |
mof |
| Gene Synonyms/Alias |
CG3025; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positively regulate their transcription through chromatin modification.Functional Description
Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the MSL complex. Dosage compensation insures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes. May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex. As part of the NSL complex may associate with promoters of X chromosomal as well as autosomal genes and positively regulate their transcription through chromatin modification. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MSEAELEQTP SAGHVQEQPI EEEHEPEQEP TDAYTIGGPP RTPVEDAAAE LSASLDVSGS 60
DQSAEQSLDL SGVQAEAAAE SEPPAKRQHR DISPISEDST PASSTSTSST RSSSSSRYDD 120
VSEAEEAPPE PEPEQPQQQQ QEEKKEDGQD QVKSPGPVEL EAQEPAQPQK QKEVVDQEIE 180
TEDEPSSDTV ICVADINPYG SGSNIDDFVM DPDAPPNAII TEVVTIPAPL HLKGTQQLGL 240
PLAAPPPPPP PPAAEQVPET PASPTDDGEE PPAVYLSPYI RSRYMQESTP GLPTRLAPRD 300
PRQRNMPPPA VVLPIQTVLS ANVEAISDDS SETSSSDDDE EEEEDEDDAL TMEHDNTSRE 360
TVITTGDPLM QKIDISENPD KIYFIRREDG TVHRGQVLQS RTTENAAAPD EYYVHYVGLN 420
RRLDGWVGRH RISDNADDLG GITVLPAPPL APDQPSTSRE MLAQQAAAAA AASSERQKRA 480
ANKDYYLSYC ENSRYDYSDR KMTRYQKRRY DEINHVQKSH AELTATQAAL EKEHESITKI 540
KYIDKLQFGN YEIDTWYFSP FPEEYGKART LYVCEYCLKY MRFRSSYAYH LHECDRRRPP 600
GREIYRKGNI SIYEVNGKEE SLYCQLLCLM AKLFLDHKVL YFDMDPFLFY ILCETDKEGS 660
HIVGYFSKEK KSLENYNVAC ILVLPPHQRK GFGKLLIAFS YELSRKEGVI GSPEKPLSDL 720
GRLSYRSYWA YTLLELMKTR CAPEQITIKE LSEMSGITHD DIIYTLQSMK MIKYWKGQNV 780
ICVTSKTIQD HLQLPQFKQP KLTIDTDYLV WSPQTAAAVV RAPGNSG
828Fasta Sequence
>O02193|mof|Drosophila melanogaster(Fruit fly)
MSEAELEQTPSAGHVQEQPIEEEHEPEQEPTDAYTIGGPPRTPVEDAAAELSASLDVSGSDQSAEQSLDLSGVQAEAAAESEPPAKRQHRDISPISEDSTPASSTSTSSTRSSSSSRYDDVSEAEEAPPEPEPEQPQQQQQEEKKEDGQDQVKSPGPVELEAQEPAQPQKQKEVVDQEIETEDEPSSDTVICVADINPYGSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAAPPPPPPPPAAEQVPETPASPTDDGEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDDALTMEHDNTSRETVITTGDPLMQKIDISENPDKIYFIRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPAPPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSPQTAAAVVRAPGNSG
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR000953--Chromo/shadow_dom
IPR016197--Chromodomain-like
IPR002717--HAT_MYST-type
IPR025995--Tudor-knot
|
| PROSITE |
PS51726--MYST_HAT
|
| Pfam |
PF01853--MOZ_SAS
PF11717--Tudor-knot
|
| Gene Ontology |
GO:0072487--C:MSL complex
GO:0044545--C:NSL complex
GO:0000228--C:nuclear chromosome
GO:0005634--C:nucleus
GO:0005705--C:polytene chromosome interband
GO:0005667--C:transcription factor complex
GO:0000805--C:X chromosome
GO:0016456--C:X chromosome located dosage compensation complex, transcription activating
GO:0003682--F:chromatin binding
GO:0004402--F:histone acetyltransferase activity
GO:0046972--F:histone acetyltransferase activity (H4-K16 specific)
GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0046872--F:metal ion binding
GO:0003729--F:mRNA binding
GO:0071479--P:cellular response to ionizing radiation
GO:0000077--P:DNA damage checkpoint
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0006281--P:DNA repair
GO:0007549--P:dosage compensation
GO:0009047--P:dosage compensation by hyperactivation of X chromosome
GO:0016573--P:histone acetylation
GO:0043984--P:histone H4-K16 acetylation
GO:0043066--P:negative regulation of apoptotic process
GO:0018394--P:peptidyl-lysine acetylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:2000873--P:regulation of histone H4 acetylation involved in response to DNA damage stimulus
GO:0010212--P:response to ionizing radiation
|
