dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000230
Uniprot Accession O02108; CDC37_CAEEL;
Genbank Protein ID NP_001040820.1;
Genbank Nucleotide ID NM_001047355.3;
Protein Name Probable Hsp90 co-chaperone cdc37
Protein Synonyms/Alias Cell division cycle-related protein 37;Hsp90 chaperone protein kinase-targeting subunit;
Gene Name cdc-37
Gene Synonyms/Alias W08F4.8;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
14KWKDIEVSDDEDDTHPhospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 21081558; 19060867; 18806794
Sequence
(Fasta)
MPIDYSKWKD IEVSDDEDDT HPNIDTPSLF RWRHQARLER MAEKKMEQEK IDKEKGTTSK 60
KMEELEKKLA AADVTDKSDI QKQIDEVKAQ EEAWRKKEAE LEEKERLEPW NVDTIGHEAF 120
STSRINKITE KKPQAPKTDE EDTHAMSTFF ETHESLLEKM AVLKNGAKST ELFLAEHPHM 180
ASEYTANWLT IEALNAAIDF NEEKMKTMAE QCIIIQYLLE LSKSLNAVAT NTTVQKQFFK 240
KFEAAEPVYM KHYQDEVKAF EDRLRTRAQT KRDAAMEEAE AEEKAERMKS APGGIDPQEV 300
FEQLPEEMRK CFEAHDIEAL KGVAQKMDEE VFKYHFDRCI ASGLWVPGKA DDDDDDEEAA 360
PAEEEPTTSS 371
Keyword

KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome

Interpro

IPR004918--Cdc37
IPR013873--Cdc37_C
IPR013874--Cdc37_Hsp90-bd
IPR013855--Cdc37_N_dom

PROSITE
Pfam

PF08564--CDC37_C
PF08565--CDC37_M
PF03234--CDC37_N

Gene Ontology

GO:0005737--C:cytoplasm
GO:0051087--F:chaperone binding
GO:0031072--F:heat shock protein binding
GO:0051082--F:unfolded protein binding
GO:0006457--P:protein folding
GO:0050821--P:protein stabilization