| Tag |
Content |
| dbPAF ID |
dbPAF-0000224 |
| Uniprot Accession |
O02002; CASP1_DROME; Q9W1N0;
|
| Genbank Protein ID |
NP_476974.1;
|
| Genbank Nucleotide ID |
NM_057626.4;
|
| Protein Name |
Caspase-1 |
| Protein Synonyms/Alias |
|
| Gene Name |
Dcp-1 |
| Gene Synonyms/Alias |
CG5370; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors.Functional Description
Involved in the activation cascade of caspases responsible for apoptosis execution (By similarity). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Loss of zygotic DCP-1 function causes larval lethality and melanotic tumors. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 51 | VGGATAASPLPANKF | PhosphoPep 2.0;curated | 19060867; 22817900 |
|
Sequence
(Fasta) | MTDECVTRNY GVGIRSPNGS ENRGSFIMAD NTDAKGCTPE SLVVGGATAA SPLPANKFVA 60
RMPVERYASE YNMSHKHRGV ALIFNHEFFD IPSLKSRTGT NVDAQELKKA FENLGFAVSV 120
HKDCKLRDIL KHVGKAAELD HTDNDCLAVA ILSHGEHGYL YAKDTQYKLD NIWHYFTATF 180
CPSLAGKPKL FFIQACQGDR LDGGITLEKG VTETDGESST SYKIPIHADF LFSYSTIPGY 240
FSWRNINNGS WYMQSLIREL NANGKKYDLL TLLTFVNQRV ALDFESNVPA TPMMDRQKQI 300
PCLTSMLTRI LRFGDKPNGN KAG
324Fasta Sequence
>O02002|Dcp-1|Drosophila melanogaster(Fruit fly)
MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGATAASPLPANKFVARMPVERYASEYNMSHKHRGVALIFNHEFFDIPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDCKLRDILKHVGKAAELDHTDNDCLAVAILSHGEHGYLYAKDTQYKLDNIWHYFTATFCPSLAGKPKLFFIQACQGDRLDGGITLEKGVTETDGESSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKYDLLTLLTFVNQRVALDFESNVPATPMMDRQKQIPCLTSMLTRILRFGDKPNGNKAG
|
| Keyword |
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0865--Zymogen
|
| Interpro |
IPR029030--Caspase-like_dom
IPR011600--Pept_C14_caspase
IPR001309--Pept_C14_ICE_p20
IPR016129--Pept_C14_ICE_p20_AS
IPR002138--Pept_C14_p10
IPR015917--Pept_C14A_p45_core
|
| PROSITE |
PS01122--CASPASE_CYS
PS01121--CASPASE_HIS
PS50207--CASPASE_P10
PS50208--CASPASE_P20
|
| Pfam |
PF00656--Peptidase_C14
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:1990525--F:BIR domain binding
GO:0004197--F:cysteine-type endopeptidase activity
GO:0097200--F:cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0007015--P:actin filament organization
GO:0006915--P:apoptotic process
GO:0048102--P:autophagic cell death
GO:0009267--P:cellular response to starvation
GO:0007303--P:cytoplasmic transport, nurse cell to oocyte
GO:0010623--P:developmental programmed cell death
GO:0097194--P:execution phase of apoptosis
GO:0007275--P:multicellular organismal development
GO:1900074--P:negative regulation of neuromuscular synaptic transmission
GO:0016322--P:neuron remodeling
GO:0045476--P:nurse cell apoptotic process
GO:0048477--P:oogenesis
GO:0007300--P:ovarian nurse cell to oocyte transport
GO:0010508--P:positive regulation of autophagy
GO:0016239--P:positive regulation of macroautophagy
GO:0012501--P:programmed cell death
GO:0035071--P:salivary gland cell autophagic cell death
|
