dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000223
Uniprot Accession O01991; EF2K_CAEEL; O01992; Q20309; Q8MYP9;
Genbank Protein ID NP_001022572.1; NP_001022573.1;
Genbank Nucleotide ID NM_001027401.2; NM_001027402.3;
Protein Name Eukaryotic elongation factor 2 kinase
Protein Synonyms/Alias
Gene Name efk-1
Gene Synonyms/Alias F42A10.4;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)		 Phosphorylates 2 adjacent threonine residues, 'Thr-57' and 'Thr-59', in the N-terminus of eukaryotic elongation factor-2. Binds calmodulin (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
27EASARTFSLNASKMVdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
332VAAKQKKSCIVPPTVdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
348EARRNRISSECVHVEdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
349ARRNRISSECVHVEHdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
372KRKTLNQSSTDLSAKdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 16381945; 23193290; 21081558; 19060867; 18806794
480SSRQTRDTEKDEFWKdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;curated19530675; 16381945; 23193290; 21081558; 18806794
Sequence
(Fasta)		MTIDTTNESD NSPTNSPGLE ASARTFSLNA SKMVRITDDY ADEVFIEQND VVIEKPRMDP 60
LHVRKLMETW RKAARRARTN YIDPWDEFNI HEYPVQRAKR YRYSAIRKQW TEDIVDVRLH 120
PDSFARGAMR ECYRLKKCSK HGTSQDWSSN YVAKRYICQV DRRVLFDDVR LQMDAKLWAE 180
EYNRYNPPKK IDIVQMCVIE MIDVKGSPLY HLEHFIEGKY IKYNSNSGFV SNAARLTPQA 240
FSHFTFERSG HQMMVVDIQG VGDLYTDPQI HTVVGTDYGD GNLGTRGMAL FFHSHRCNDI 300
CETMDLSNFE LSPPEIEATE VAMEVAAKQK KSCIVPPTVF EARRNRISSE CVHVEHGISM 360
DQLRKRKTLN QSSTDLSAKS HNEDCVCPEC IPVVEQLCEP CSEDEEDEEE DYPRSEKSGN 420
SQKSRRSRMS ISTRSSGDES ASRPRKCGFV DLNSLRQRHD SFRSSVGTYS MNSSRQTRDT 480
EKDEFWKVLR KQSVPANILS LQLQQMAANL ENDEDVPQVT GHQFSVLGQI HIDLSRYHEL 540
GRFVEVDSEH KEMLEGSEND ARVPIKYDKQ SAIFHLDIAR KCGILEAVLT SAHIVLGLPH 600
ELLKEVTVDD LFPNGFGEQE NGIRADKGQK PCDLEEFGSD LMEIAAEMGD KGAMLYMAHA 660
YETGQHLGPN RRTDYKKSID WYQRVVGFQE EEELDSDCGK TTFSSFAPLT RHEILAKMAE 720
MYKEGGYGLN QDFERAYGLF NEAAEAAMEA MNGKLANKYY EKAEMCGE 769
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0106--Calcium
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR017400--eEF-2K
IPR011009--Kinase-like_dom
IPR004166--MHCK_EF2_kinase
IPR006597--Sel1-like
IPR011990--TPR-like_helical_dom
PROSITE

PS51158--ALPHA_KINASE
Pfam

PF02816--Alpha_kinase
Gene Ontology

GO:0005524--F:ATP binding
GO:0005509--F:calcium ion binding
GO:0004686--F:elongation factor-2 kinase activity
GO:0006468--P:protein phosphorylation