| Tag |
Content |
| dbPAF ID |
dbPAF-0000191 |
| Uniprot Accession |
O01700; DLK1_CAEEL; B3KYB4; Q7JKE7; Q7JKE9;
|
| Genbank Protein ID |
NP_001021443.1; NP_001021444.1; NP_001021445.1; NP_001129769.1;
|
| Genbank Nucleotide ID |
NM_001026272.3; NM_001026273.5; NM_001026274.3; NM_001136297.2;
|
| Protein Name |
Mitogen-activated protein kinase kinase kinase dlk-1 |
| Protein Synonyms/Alias |
DAP kinase-like kinase;Death-associated protein kinase-like kinase; |
| Gene Name |
dlk-1 |
| Gene Synonyms/Alias |
F33E2.2; |
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View all) |
Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4. Has a role in axonal regrowth following axotomy and synaptopgenesis. Also promotes tubulin post-translational modifications that protect microtubules.Functional Description
Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4. Has a role in axonal regrowth following axotomy and synaptopgenesis. Also promotes tubulin post-translational modifications that protect microtubules. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 680 | HGVISCSSPRSSSKL | PhosphoPep 2.0 | 19060867 |
|
Sequence
(Fasta) | MTSTTMVTTL DLVTPTSEEQ PGPAPESSDF STVVLSPDGS ELVTQSAPNT PIQHREQANA 60
EFGQKEGSPD PKNMVAATGN ASKPSLNSFY ADGLGQLRNG LFSCFQPVFG YFGTKTTVEI 120
EKSEDELWEI PFDAISELEW LGSGSQGAVF RGQLENRTVA VKKVNQLKET EIKHLRHLRH 180
QNIIEFLGVC SKSPCYCIVM EYCSKGQLCT VLKSRNTITR ELFAQWVKEI ADGMHYLHQN 240
KVIHRDLKSP NILISAEDSI KICDFGTSHM QKKMDSTMMS FCGTVSWMAP EMIKKQPCNE 300
KVDVYSFGVV LWEMLTRETP YANIAQMAII FGVGTNILSL PMPEEAPKGL VLLIKQCLSQ 360
KGRNRPSFSH IRQHWEIFKP ELFEMTEEEW QLAWDSYREF AKCIQYPSTV TRDHGGPKSA 420
FAMEEEIQRK RHEQLNHIKD IRNMYEMKLK RTNKMYDKLQ GCFTELKLKE SELAEWEKDL 480
TEREQWHNQN SPKAVAAPRA QLRGYPNEGY DDMSSDEDVQ PCRGSPYRCS NTSSSSGVQS 540
SPFSRQSSSR SSAGQQTRRS EGANPPKILR NDAIRHSGSY WETLGGARGS PARDSGFSQD 600
SGMWSAGAGS CTAINGGGQQ VCYSQTLYRN GDGRWSDGRI ASRRRVSTSV NKSTAVPGQP 660
VFFTRDSPSR VPHGVISCSS PRSSSKLNRS SYPSRNAPHQ LEDGCCCAHA RAPRAKSIAV 720
PMTSSSRARS PTPYDNDFEN AESFVDPESP KNLKNLEKIV NLPESTSYDE ALCNSDVTMN 780
PIYTSPITTY SNPCHVELVD EENANDVDLT SSMDSRRSRS DDADVESSEE DEGNGNNILN 840
TSMESEDLRY RIDTSQSTMM SSLERSLEIG ATRSDGLSDN EMRVQAVKMS IKTHRRTGSN 900
PQALIHQCID EYTTSATDDS DDAGAVRI
929Fasta Sequence
>O01700|dlk-1|Caenorhabditis elegans
MTSTTMVTTLDLVTPTSEEQPGPAPESSDFSTVVLSPDGSELVTQSAPNTPIQHREQANAEFGQKEGSPDPKNMVAATGNASKPSLNSFYADGLGQLRNGLFSCFQPVFGYFGTKTTVEIEKSEDELWEIPFDAISELEWLGSGSQGAVFRGQLENRTVAVKKVNQLKETEIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLKSRNTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHIRQHWEIFKPELFEMTEEEWQLAWDSYREFAKCIQYPSTVTRDHGGPKSAFAMEEEIQRKRHEQLNHIKDIRNMYEMKLKRTNKMYDKLQGCFTELKLKESELAEWEKDLTEREQWHNQNSPKAVAAPRAQLRGYPNEGYDDMSSDEDVQPCRGSPYRCSNTSSSSGVQSSPFSRQSSSRSSAGQQTRRSEGANPPKILRNDAIRHSGSYWETLGGARGSPARDSGFSQDSGMWSAGAGSCTAINGGGQQVCYSQTLYRNGDGRWSDGRIASRRRVSTSVNKSTAVPGQPVFFTRDSPSRVPHGVISCSSPRSSSKLNRSSYPSRNAPHQLEDGCCCAHARAPRAKSIAVPMTSSSRARSPTPYDNDFENAESFVDPESPKNLKNLEKIVNLPESTSYDEALCNSDVTMNPIYTSPITTYSNPCHVELVDEENANDVDLTSSMDSRRSRSDDADVESSEEDEGNGNNILNTSMESEDLRYRIDTSQSTMMSSLERSLEIGATRSDGLSDNEMRVQAVKMSIKTHRRTGSNPQALIHQCIDEYTTSATDDSDDAGAVRI
|
| Keyword |
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0770--Synapse
KW-0808--Transferase
KW-0832--Ubl conjugation
|
| Interpro |
IPR011009--Kinase-like_dom
IPR017419--MAP3K12_MAP3K13
IPR000719--Prot_kinase_dom
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
|
| PROSITE |
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
|
| Pfam |
PF00069--Pkinase
|
| Gene Ontology |
GO:0030054--C:cell junction
GO:0005622--C:intracellular
GO:0043025--C:neuronal cell body
GO:0045202--C:synapse
GO:0005524--F:ATP binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0046872--F:metal ion binding
GO:0008022--F:protein C-terminus binding
GO:0000186--P:activation of MAPKK activity
GO:0048677--P:axon extension involved in regeneration
GO:0048689--P:formation of growth cone in injured axon
GO:1903616--P:MAPK cascade involved in axon regeneration
GO:0046777--P:protein autophosphorylation
GO:0050807--P:regulation of synapse organization
|
