dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000190 |
| Uniprot Accession | O01683; SSP1B_CAEEL; |
| Genbank Protein ID | NP_491688.1; |
| Genbank Nucleotide ID | NM_059287.3; |
| Protein Name | FACT complex subunit ssrp1-B |
| Protein Synonyms/Alias | Facilitates chromatin transcription complex subunit ssrp1-B;HMG box-containing protein 3;Structure-specific recognition protein 1-B; |
| Gene Name | hmg-3 |
| Gene Synonyms/Alias | C32F10.5; |
| Organism | Caenorhabditis elegans |
| NCBI Taxa ID | 6239 |
| Functional Description (View all) |
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MTELKFKGVY VEDIGHLTCG TLTLTENSIN FIGDKGGKSV YITGTDVDKL KWQKLGNKPG 60 LRVGLSDGGA HRFGGFLDDD LQKIQSFTSS NWSKSINQSN LFINGWNYGQ ADVKGKNIEF 120 SWENEPIFEI PCTNVSNVIA NKNEAILEFH QNEQSKVQLM EMRFHMPVDL ENEEDTDKVE 180 EFKKAVLAYA GLEAETEQPI CLLTDILCTT PRGRYDIKVY PTSIALHGKT YDYKIPVKTI 240 NRLFLVPHKD GRQVYFVLSL NPPIRQGQTH YSYLIFEFGK DEEEDLELSL TDEQLDYFNG 300 NLQREMTGPI YETISILFKS ICNLKVTVPG RFLGSSGTPA IQCTHRQNLG LLYPMEKGFL 360 FIQKPVMYIR FEEISSCHFA RSDSGTVTRT FDFEIDLKTG SSLTFSAMDK EENNKLFDYL 420 NKKEIKIRNS HRIDNKSAGY GSSDEDDIDP YKSTVKAEGR EQDDDSDDES TDEDYDLDKD 480 MKKQKNDKDS SEGSGSEPDD EYDSGSEKDA SGTGESDPDE ENIEPKKKES KEKKNKREKK 540 EKPVKEKAVK KGKKTKDPNE PKRATTAYII WFNANRNSMK EDGDTLGDVA KKAGAKWKSM 600 SADDKKEWND KAAQDKARYE AEMKEYKKNG GGVEKASGPS TKKSSDQSPG KQFKSKEHIS 660 DTDDSDDDEP LKAKKDESDA ASESSGESD |
| Keyword | KW-0158--Chromosome |
| Interpro | IPR013719--DUF1747 |
| PROSITE | PS50118--HMG_BOX_2 |
| Pfam | |
| Gene Ontology | GO:0005694--C:chromosome |