| Tag |
Content |
| dbPAF ID |
dbPAF-0000172 |
| Uniprot Accession |
O01498; STAM1_CAEEL; Q8I7I2;
|
| Genbank Protein ID |
NP_491710.2; NP_871813.1;
|
| Genbank Nucleotide ID |
NM_059309.6; NM_182013.6;
|
| Protein Name |
Signal transducing adapter molecule 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
stam-1 |
| Gene Synonyms/Alias |
pqn-19;C34G6.7; |
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View all) |
Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1.Functional Description
Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MKKQKSFPMS AYEDLLGKIT APTITVENWE GILAFCDMIN NDFEGSKTGI KSLRKRLNNR 60
DPHVVLLAIS VLDSCWANCE ERFRKEVSSA QFINELKALC TSSQRQVAEK MRLTVQKWVD 120
TECKTEQSLS LIVTLHKNLV ADGYSFVVDD PKSKTKAIDA KFANDPNYVG SAQEEEAIAK 180
AIAASLADAE KQEKAKKSTS TMYPSAKASS PAVQTNSNIP EKNVRALYDF EAAESNELSF 240
VAGDIITITD ESNPHWWTGR IGTQQGLFPS SFVTNQLDDL KSKETDSSQK APEVVASINE 300
AILVRCLQVL HECDPTGERQ DPEDLAQLEA ASYAQGNLID AHLASIDRQS NSLAQIDVAI 360
RDVLALYDDA IQKGGFQHQS QGMYQQPMQQ YNYQQPPNRA YYPPTGPVQQ QQPQQYPPQH 420
YPAPGAQPQY ACPPNSVPQP QQQQQQWPAP SSQPQQY
458Fasta Sequence
>O01498|stam-1|Caenorhabditis elegans
MKKQKSFPMSAYEDLLGKITAPTITVENWEGILAFCDMINNDFEGSKTGIKSLRKRLNNRDPHVVLLAISVLDSCWANCEERFRKEVSSAQFINELKALCTSSQRQVAEKMRLTVQKWVDTECKTEQSLSLIVTLHKNLVADGYSFVVDDPKSKTKAIDAKFANDPNYVGSAQEEEAIAKAIAASLADAEKQEKAKKSTSTMYPSAKASSPAVQTNSNIPEKNVRALYDFEAAESNELSFVAGDIITITDESNPHWWTGRIGTQQGLFPSSFVTNQLDDLKSKETDSSQKAPEVVASINEAILVRCLQVLHECDPTGERQDPEDLAQLEAASYAQGNLIDAHLASIDRQSNSLAQIDVAIRDVLALYDDAIQKGGFQHQSQGMYQQPMQQYNYQQPPNRAYYPPTGPVQQQQPQQYPPQHYPAPGAQPQYACPPNSVPQPQQQQQQWPAPSSQPQQY
|
| Keyword |
KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0969--Cilium
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0967--Endosome
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport
|
| Interpro |
IPR008942--ENTH_VHS
IPR001452--SH3_domain
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR018205--VHS_subgr
|
| PROSITE |
PS50002--SH3
PS50330--UIM
PS50179--VHS
|
| Pfam |
PF00018--SH3_1
PF00790--VHS
|
| Gene Ontology |
GO:0005929--C:cilium
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0033565--C:ESCRT-0 complex
GO:0008022--F:protein C-terminus binding
GO:0043130--F:ubiquitin binding
GO:0008333--P:endosome to lysosome transport
GO:0048013--P:ephrin receptor signaling pathway
GO:0006886--P:intracellular protein transport
GO:0007275--P:multicellular organismal development
GO:0043409--P:negative regulation of MAPK cascade
GO:0097499--P:protein localization to nonmotile primary cilium
GO:0034606--P:response to hermaphrodite contact
|
