| Tag |
Content |
| dbPAF ID |
dbPAF-0000167 |
| Uniprot Accession |
O01382; DRICE_DROME; Q9VAH1;
|
| Genbank Protein ID |
NP_524551.2;
|
| Genbank Nucleotide ID |
NM_079827.3;
|
| Protein Name |
Caspase |
| Protein Synonyms/Alias |
drICE; |
| Gene Name |
Drice |
| Gene Synonyms/Alias |
ICE;CG7788; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.Functional Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MDATNNGESA DQVGIRVGNP EQPNDHTDAL GSVGSGGAGS SGLVAGSSHP YGSGAIGQLA 60
NGYSSPSSSY RKNVAKMVTD RHAAEYNMRH KNRGMALIFN HEHFEVPTLK SRAGTNVDCE 120
NLTRVLKQLD FEVTVYKDCR YKDILRTIEY AASQNHSDSD CILVAILSHG EMGYIYAKDT 180
QYKLDNIWSF FTANHCPSLA GKPKLFFIQA CQGDRLDGGV TMQRSQTETD GDSSMSYKIP 240
VHADFLIAYS TVPGFYSWRN TTRGSWFMQS LCAELAANGK RLDILTLLTF VCQRVAVDFE 300
SCTPDTPEMH QQKQIPCITT MLTRILRFSD KQLAPAGRV
Fasta Sequence
>O01382|Drice|Drosophila melanogaster(Fruit fly)
MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPYGSGAIGQLANGYSSPSSSYRKNVAKMVTDRHAAEYNMRHKNRGMALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAASQNHSDSDCILVAILSHGEMGYIYAKDTQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTMQRSQTETDGDSSMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILRFSDKQLAPAGRV
|
| Keyword |
KW-0002--3D-structure
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0865--Zymogen
|
| Interpro |
IPR029030--Caspase-like_dom
IPR011600--Pept_C14_caspase
IPR001309--Pept_C14_ICE_p20
IPR016129--Pept_C14_ICE_p20_AS
IPR002138--Pept_C14_p10
IPR015917--Pept_C14A_p45_core
|
| PROSITE |
PS01122--CASPASE_CYS
PS01121--CASPASE_HIS
PS50207--CASPASE_P10
PS50208--CASPASE_P20
|
| Pfam |
PF00656--Peptidase_C14
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:1990525--F:BIR domain binding
GO:0004197--F:cysteine-type endopeptidase activity
GO:0097153--F:cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200--F:cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0006915--P:apoptotic process
GO:0010623--P:developmental programmed cell death
GO:0097194--P:execution phase of apoptosis
GO:0016322--P:neuron remodeling
GO:0045476--P:nurse cell apoptotic process
GO:0046672--P:positive regulation of compound eye retinal cell programmed cell death
GO:2001269--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0012501--P:programmed cell death
GO:0046668--P:regulation of retinal cell programmed cell death
GO:0010165--P:response to X-ray
GO:0035070--P:salivary gland histolysis
GO:0048515--P:spermatid differentiation
GO:0035103--P:sterol regulatory element binding protein cleavage
|
