dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000162
Uniprot Accession O00767; ACOD_HUMAN; B2R5U0; D3DR68; Q16150; Q53GR9; Q5W037; Q5W038; Q6GSS4; Q96KF6; Q9BS07; Q9Y695;
Genbank Protein ID NP_005054.3;
Genbank Nucleotide ID NM_005063.4;
Protein Name Acyl-CoA desaturase
Protein Synonyms/Alias Delta(9)-desaturase;Delta-9 desaturase;Fatty acid desaturase;Stearoyl-CoA desaturase;hSCD1;
Gene Name SCD
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
14QDDISSSYTTTTTITPhosphoSitePlus22135298
41KLETMPLYLEDDIRPPhosphoSitePlus22135298
55PDIKDDIYDPTYKDKPhosphoSitePlus;curated22135298; 25627689
59DDIYDPTYKDKEGPSPhosphoSitePlus22135298
71GPSPKVEYVWRNIILPHOSIDA21081558
80WRNIILMSLLHLGALPhosphoSitePlus22135298
91LGALYGITLIPTCKFPhosphoSitePlus22135298
95YGITLIPTCKFYTWLPhosphoSitePlus22135298
198PAVKEKGSTLDLSDLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 18669648; 18578522; 19651622;
199AVKEKGSTLDLSDLEdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 21406692; 18988627; 21081558;
203KGSTLDLSDLEAEKLdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 16381945; 23193290; 18988627; 21081558; 19060867;
351ILARIKRTGDGNYKSdbPTM 3.0;HPRD 9;PhosphoSitePlus19651622; 16381945; 23193290; 18988627; 22135298
Sequence
(Fasta)		MPAHLLQDDI SSSYTTTTTI TAPPSRVLQN GGDKLETMPL YLEDDIRPDI KDDIYDPTYK 60
DKEGPSPKVE YVWRNIILMS LLHLGALYGI TLIPTCKFYT WLWGVFYYFV SALGITAGAH 120
RLWSHRSYKA RLPLRLFLII ANTMAFQNDV YEWARDHRAH HKFSETHADP HNSRRGFFFS 180
HVGWLLVRKH PAVKEKGSTL DLSDLEAEKL VMFQRRYYKP GLLMMCFILP TLVPWYFWGE 240
TFQNSVFVAT FLRYAVVLNA TWLVNSAAHL FGYRPYDKNI SPRENILVSL GAVGEGFHNY 300
HHSFPYDYSA SEYRWHINFT TFFIDCMAAL GLAYDRKKVS KAAILARIKR TGDGNYKSG 360
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0408--Iron
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0479--Metal-binding
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001522--Fatty_acid_desaturase-1_C
IPR015876--Fatty_acid_desaturase-1_core
PROSITE

PS00476--FATTY_ACID_DESATUR_1
Pfam
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005506--F:iron ion binding
GO:0016491--F:oxidoreductase activity
GO:0004768--F:stearoyl-CoA 9-desaturase activity
GO:0044255--P:cellular lipid metabolic process
GO:0035338--P:long-chain fatty-acyl-CoA biosynthetic process
GO:0044281--P:small molecule metabolic process
GO:0019432--P:triglyceride biosynthetic process
GO:0006636--P:unsaturated fatty acid biosynthetic process