dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000161
Uniprot Accession O00764; PDXK_HUMAN; Q7Z2Y0; Q9BS02;
Genbank Protein ID NP_003672.1; XP_005261256.1; XP_011528062.1; XP_011528063.1;
Genbank Nucleotide ID NM_003681.4; XM_005261199.2; XM_011529760.1; XM_011529761.1;
Protein Name Pyridoxal kinase
Protein Synonyms/Alias Pyridoxine kinase;
Gene Name PDXK
Gene Synonyms/Alias C21orf124;C21orf97;PKH;PNK;PRED79;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
59WKGQVLNSDELQELYdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19369195; 16381945; 23193290; 21081558; 19060867; 22135298;
84YDYVLTGYTRDKSFLdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19369195; 16381945; 23193290; 21081558; 19060867; 22135298;
164LSGRKIHSQEEALRVdbPTM 3.0;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19369195; 16381945; 23193290; 21081558; 19060867; 22135298;
196DLPSPQGSNYLIVLGdbPTM 3.019369195; 16381945; 23193290
204NYLIVLGSQRRRNPAdbPTM 3.019369195; 16381945; 23193290
213RRRNPAGSVVMERIRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 19369195; 16381945; 23193290; 18988627; 21081558;
259LKVACEKTVSTLHHVdbPTM 3.0;PhosphoPep 2.019369195; 16381945; 23193290; 19060867
261VACEKTVSTLHHVLQPhosphoSitePlus22135298
270LHHVLQRTIQCAKAQPhosphoSitePlus22135298
285AGEGVRPSPMQLELRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18691976; 19369195; 16381945; 23193290; 18988627; 21081558;
Sequence
(Fasta)		MEEECRVLSI QSHVIRGYVG NRAATFPLQV LGFEIDAVNS VQFSNHTGYA HWKGQVLNSD 60
ELQELYEGLR LNNMNKYDYV LTGYTRDKSF LAMVVDIVQE LKQQNPRLVY VCDPVLGDKW 120
DGEGSMYVPE DLLPVYKEKV VPLADIITPN QFEAELLSGR KIHSQEEALR VMDMLHSMGP 180
DTVVITSSDL PSPQGSNYLI VLGSQRRRNP AGSVVMERIR MDIRKVDAVF VGTGDLFAAM 240
LLAWTHKHPN NLKVACEKTV STLHHVLQRT IQCAKAQAGE GVRPSPMQLE LRMVQSKRDI 300
EDPEIVVQAT VL 313
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
Interpro

IPR013749--PM/HMP-P_kinase-1
IPR004625--PyrdxlP_synth_PyrdxlKinase
IPR029056--Ribokinase-like
PROSITE
Pfam

PF08543--Phos_pyr_kin
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0031403--F:lithium ion binding
GO:0000287--F:magnesium ion binding
GO:0030955--F:potassium ion binding
GO:0042803--F:protein homodimerization activity
GO:0008478--F:pyridoxal kinase activity
GO:0030170--F:pyridoxal phosphate binding
GO:0031402--F:sodium ion binding
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0009443--P:pyridoxal 5'-phosphate salvage
GO:0042823--P:pyridoxal phosphate biosynthetic process
GO:0044281--P:small molecule metabolic process
GO:0042816--P:vitamin B6 metabolic process
GO:0006766--P:vitamin metabolic process
GO:0006767--P:water-soluble vitamin metabolic process