dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000160
Uniprot Accession O00763; ACACB_HUMAN; A6NK36; Q16852; Q1HEC1; Q6KE87; Q6KE89; Q6TY48;
Genbank Protein ID NP_001084.3; XP_005253933.1; XP_006719428.1; XP_006719430.1; XP_011536561.1; XP_011536562.1; XP_011536563.1; XP_011536564.1;
Genbank Nucleotide ID NM_001093.3; XM_005253876.3; XM_006719365.2; XM_006719367.2; XM_011538259.1; XM_011538260.1; XM_011538261.1; XM_011538262.1;
Protein Name Acetyl-CoA carboxylase 2
Protein Synonyms/Alias ACC-beta;
Gene Name ACACB
Gene Synonyms/Alias ACC2;ACCB;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 34 (View all)
PositionPeptidesSourceReferences ( PMIDs )
35DSKPITKSKSEANLIPhosphoSitePlus;UniProt;curated22135298; 24275569; 24972180
37KPITKSKSEANLIPSdbPTM 3.0;HPRD 918669648; 16381945; 23193290; 18988627
70EGHTLPKTPSQAEPAPhosphoSitePlus;UniProt22135298; 24275569
72HTLPKTPSQAEPASHcurated24972180
91DAGRRRNSLPPSHQKPhosphoSitePlus;UniProt22135298; 24275569
95RRNSLPPSHQKPPRNPhosphoSitePlus;UniProt22135298; 24275569
192RESTRKGSRASLGALPhosphoSitePlus;curated22135298; 24972180
195TRKGSRASLGALSLEPhosphoSitePlus;curated22135298; 24972180
200RASLGALSLEAYLTTPhosphoSitePlus;UniProt22135298; 24275569
216EAETRVPTMRPSMSGPhosphoSitePlus22135298
220RVPTMRPSMSGLHLVPhosphoSitePlus;curated22135298; 24972180
222PTMRPSMSGLHLVKRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus12488245; 16381945; 23193290; 12068056; 12391032; 12413941;
246HRDFTVASPAEFVTRPhosphoSitePlus;curated22135298; 25850435
469KGIRKAESAEDFPILPhosphoSitePlus;UniProt22135298; 24275569
808GQVLPADSLLNLVDVPhosphoSitePlus22135298
865LLSYNGNSYTTYMKEdbPTM 3.0;PhosphoSitePlus20562096; 16381945; 23193290; 22135298
866LSYNGNSYTTYMKEEdbPTM 3.0;PhosphoSitePlus20562096; 16381945; 23193290; 22135298
895FEKENDPTVLRSPSAPhosphoSitePlus22135298
1340NRMTVPISITNPDLLPhosphoSitePlus22135298
1342MTVPISITNPDLLRHdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated20166139; 16381945; 23193290; 18988627; 22135298; 24275569;
Sequence
(Fasta)		MVLLLCLSCL IFSCLTFSWL KIWGKMTDSK PITKSKSEAN LIPSQEPFPA SDNSGETPQR 60
NGEGHTLPKT PSQAEPASHK GPKDAGRRRN SLPPSHQKPP RNPLSSSDAA PSPELQANGT 120
GTQGLEATDT NGLSSSARPQ GQQAGSPSKE DKKQANIKRQ LMTNFILGSF DDYSSDEDSV 180
AGSSRESTRK GSRASLGALS LEAYLTTGEA ETRVPTMRPS MSGLHLVKRG REHKKLDLHR 240
DFTVASPAEF VTRFGGDRVI EKVLIANNGI AAVKCMRSIR RWAYEMFRNE RAIRFVVMVT 300
PEDLKANAEY IKMADHYVPV PGGPNNNNYA NVELIVDIAK RIPVQAVWAG WGHASENPKL 360
PELLCKNGVA FLGPPSEAMW ALGDKIASTV VAQTLQVPTL PWSGSGLTVE WTEDDLQQGK 420
RISVPEDVYD KGCVKDVDEG LEAAERIGFP LMIKASEGGG GKGIRKAESA EDFPILFRQV 480
QSEIPGSPIF LMKLAQHARH LEVQILADQY GNAVSLFGRD CSIQRRHQKI VEEAPATIAP 540
LAIFEFMEQC AIRLAKTVGY VSAGTVEYLY SQDGSFHFLE LNPRLQVEHP CTEMIADVNL 600
PAAQLQIAMG VPLHRLKDIR LLYGESPWGV TPISFETPSN PPLARGHVIA ARITSENPDE 660
GFKPSSGTVQ ELNFRSSKNV WGYFSVAATG GLHEFADSQF GHCFSWGENR EEAISNMVVA 720
LKELSIRGDF RTTVEYLINL LETESFQNND IDTGWLDYLI AEKVQAEKPD IMLGVVCGAL 780
NVADAMFRTC MTDFLHSLER GQVLPADSLL NLVDVELIYG GVKYILKVAR QSLTMFVLIM 840
NGCHIEIDAH RLNDGGLLLS YNGNSYTTYM KEEVDSYRIT IGNKTCVFEK ENDPTVLRSP 900
SAGKLTQYTV EDGGHVEAGS SYAEMEVMKM IMTLNVQERG RVKYIKRPGA VLEAGCVVAR 960
LELDDPSKVH PAEPFTGELP AQQTLPILGE KLHQVFHSVL ENLTNVMSGF CLPEPVFSIK 1020
LKEWVQKLMM TLRHPSLPLL ELQEIMTSVA GRIPAPVEKS VRRVMAQYAS NITSVLCQFP 1080
SQQIATILDC HAATLQRKAD REVFFINTQS IVQLVQRYRS GIRGYMKTVV LDLLRRYLRV 1140
EHHFQQAHYD KCVINLREQF KPDMSQVLDC IFSHAQVAKK NQLVIMLIDE LCGPDPSLSD 1200
ELISILNELT QLSKSEHCKV ALRARQILIA SHLPSYELRH NQVESIFLSA IDMYGHQFCP 1260
ENLKKLILSE TTIFDVLPTF FYHANKVVCM ASLEVYVRRG YIAYELNSLQ HRQLPDGTCV 1320
VEFQFMLPSS HPNRMTVPIS ITNPDLLRHS TELFMDSGFS PLCQRMGAMV AFRRFEDFTR 1380
NFDEVISCFA NVPKDTPLFS EARTSLYSED DCKSLREEPI HILNVSIQCA DHLEDEALVP 1440
ILRTFVQSKK NILVDYGLRR ITFLIAQEKE FPKFFTFRAR DEFAEDRIYR HLEPALAFQL 1500
ELNRMRNFDL TAVPCANHKM HLYLGAAKVK EGVEVTDHRF FIRAIIRHSD LITKEASFEY 1560
LQNEGERLLL EAMDELEVAF NNTSVRTDCN HIFLNFVPTV IMDPFKIEES VRYMVMRYGS 1620
RLWKLRVLQA EVKINIRQTT TGSAVPIRLF ITNESGYYLD ISLYKEVTDS RSGNIMFHSF 1680
GNKQGPQHGM LINTPYVTKD LLQAKRFQAQ TLGTTYIYDF PEMFRQALFK LWGSPDKYPK 1740
DILTYTELVL DSQGQLVEMN RLPGGNEVGM VAFKMRFKTQ EYPEGRDVIV IGNDITFRIG 1800
SFGPGEDLLY LRASEMARAE GIPKIYVAAN SGARIGMAEE IKHMFHVAWV DPEDPHKGFK 1860
YLYLTPQDYT RISSLNSVHC KHIEEGGESR YMITDIIGKD DGLGVENLRG SGMIAGESSL 1920
AYEEIVTISL VTCRAIGIGA YLVRLGQRVI QVENSHIILT GASALNKVLG REVYTSNNQL 1980
GGVQIMHYNG VSHITVPDDF EGVYTILEWL SYMPKDNHSP VPIITPTDPI DREIEFLPSR 2040
APYDPRWMLA GRPHPTLKGT WQSGFFDHGS FKEIMAPWAQ TVVTGRARLG GIPVGVIAVE 2100
TRTVEVAVPA DPANLDSEAK IIQQAGQVWF PDSAYKTAQA VKDFNREKLP LMIFANWRGF 2160
SGGMKDMYDQ VLKFGAYIVD GLRQYKQPIL IYIPPYAELR GGSWVVIDAT INPLCIEMYA 2220
DKESRGGVLE PEGTVEIKFR KKDLIKSMRR IDPAYKKLME QLGEPDLSDK DRKDLEGRLK 2280
AREDLLLPIY HQVAVQFADF HDTPGRMLEK GVISDILEWK TARTFLYWRL RRLLLEDQVK 2340
QEILQASGEL SHVHIQSMLR RWFVETEGAV KAYLWDNNQV VVQWLEQHWQ AGDGPRSTIR 2400
ENITYLKHDS VLKTIRGLVE ENPEVAVDCV IYLSQHISPA ERAQVVHLLS TMDSPAST 2459
Keyword

KW-0002--3D-structure
KW-0021--Allosteric enzyme
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0092--Biotin
KW-0181--Complete proteome
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0436--Ligase
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0809--Transit peptide
Interpro

IPR013537--AcCoA_COase_cen
IPR011761--ATP-grasp
IPR013815--ATP_grasp_subdomain_1
IPR013816--ATP_grasp_subdomain_2
IPR005481--BC-like_N
IPR011764--Biotin_carboxylation_dom
IPR005482--Biotin_COase_C
IPR000089--Biotin_lipoyl
IPR000022--Carboxyl_trans
IPR005479--CbamoylP_synth_lsu-like_ATP-bd
IPR029045--ClpP/crotonase-like_dom
IPR011763--COA_CT_C
IPR011762--COA_CT_N
IPR016185--PreATP-grasp_dom
IPR011054--Rudment_hybrid_motif
IPR011053--Single_hybrid_motif
PROSITE

PS50975--ATP_GRASP
PS50979--BC
PS50968--BIOTINYL_LIPOYL
PS50989--COA_CT_CTER
PS50980--COA_CT_NTER
PS00866--CPSASE_1
PS00867--CPSASE_2
Pfam

PF08326--ACC_central
PF02785--Biotin_carb_C
PF00364--Biotin_lipoyl
PF01039--Carboxyl_trans
PF00289--CPSase_L_chain
PF02786--CPSase_L_D2
Gene Ontology

GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0003989--F:acetyl-CoA carboxylase activity
GO:0005524--F:ATP binding
GO:0004075--F:biotin carboxylase activity
GO:0046872--F:metal ion binding
GO:0006084--P:acetyl-CoA metabolic process
GO:0006768--P:biotin metabolic process
GO:0006853--P:carnitine shuttle
GO:0044255--P:cellular lipid metabolic process
GO:0006112--P:energy reserve metabolic process
GO:0006633--P:fatty acid biosynthetic process
GO:2001295--P:malonyl-CoA biosynthetic process
GO:0046322--P:negative regulation of fatty acid oxidation
GO:0031325--P:positive regulation of cellular metabolic process
GO:0060421--P:positive regulation of heart growth
GO:0010884--P:positive regulation of lipid storage
GO:0051289--P:protein homotetramerization
GO:0044281--P:small molecule metabolic process
GO:0006766--P:vitamin metabolic process
GO:0006767--P:water-soluble vitamin metabolic process