| Tag |
Content |
| dbPAF ID |
dbPAF-0000159 |
| Uniprot Accession |
O00762; UBE2C_HUMAN; A6NP33; E1P5N7; G3XAB7;
|
| Genbank Protein ID |
NP_001268670.1; NP_001268671.1; NP_008950.1; NP_861515.1; NP_861516.1; NP_861517.1;
|
| Genbank Nucleotide ID |
NM_001281741.1; NM_001281742.1; NM_007019.3; NM_181799.2; NM_181800.2; NM_181801.3;
|
| Protein Name |
Ubiquitin-conjugating enzyme E2 C |
| Protein Synonyms/Alias |
(E3-independent) E2 ubiquitin-conjugating enzyme C; |
| Gene Name |
UBE2C |
| Gene Synonyms/Alias |
UBCH10; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.Functional Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF 60
KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKE 120
KWSALYDVRT ILLSIQSLLG EPNIDSPLNT HAAELWKNPT AFKKYLQETY SKQVTSQEP
180
Fasta Sequence
>O00762|UBE2C|Homo sapiens(Human)
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
|
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
|
| Interpro |
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
|
| PROSITE |
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
|
| Pfam |
PF00179--UQ_con
|
| Gene Ontology |
GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051488--P:activation of anaphase-promoting complex activity
GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051301--P:cell division
GO:0010458--P:exit from mitosis
GO:0010994--P:free ubiquitin chain polymerization
GO:0000278--P:mitotic cell cycle
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0008054--P:negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0031536--P:positive regulation of exit from mitosis
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process
|
