dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000158
Uniprot Accession O00757; F16P2_HUMAN; Q17R39; Q6FI53;
Genbank Protein ID NP_003828.2;
Genbank Nucleotide ID NM_003837.3;
Protein Name Fructose-1,6-bisphosphatase isozyme 2
Protein Synonyms/Alias
Gene Name FBP2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
17DMLTLTRYVMEKGRQPhosphoSitePlus22135298
28KGRQAKGTGELTQLLPhosphoSitePlus22135298
40QLLNSMLTAIKAISSPhosphoSitePlus22135298
210IKKKGKIYSLNEGYAPhosphoSitePlus22135298
216IYSLNEGYAKYFDAAdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 21253578; 19060867; 22135298;
219LNEGYAKYFDAATTEPhosphoSitePlus22135298
241PEDGSAPYGARYVGSPhosphoSitePlus22135298
245SAPYGARYVGSMVADPhosphoSitePlus22135298
256MVADVHRTLVYGGIFPhosphoSitePlus22135298
259DVHRTLVYGGIFLYPdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
265VYGGIFLYPANQKSPPhosphoSitePlus22135298
Sequence
(Fasta)		MTDRSPFETD MLTLTRYVME KGRQAKGTGE LTQLLNSMLT AIKAISSAVR KAGLAHLYGI 60
AGSVNVTGDE VKKLDVLSNS LVINMVQSSY STCVLVSEEN KDAIITAKEK RGKYVVCFDP 120
LDGSSNIDCL ASIGTIFAIY RKTSEDEPSE KDALQCGRNI VAAGYALYGS ATLVALSTGQ 180
GVDLFMLDPA LGEFVLVEKD VKIKKKGKIY SLNEGYAKYF DAATTEYVQK KKFPEDGSAP 240
YGARYVGSMV ADVHRTLVYG GIFLYPANQK SPKGKLRLLY ECNPVAYIIE QAGGLATTGT 300
QPVLDVKPEA IHQRVPLILG SPEDVQEYLT CVQKNQAGS
Keyword

KW-0002--3D-structure
KW-0021--Allosteric enzyme
KW-0106--Calcium
KW-0119--Carbohydrate metabolism
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0312--Gluconeogenesis
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR000146--FBPase_class-1/SBPase
IPR028343--FBPtase
IPR020548--Fructose_bisphosphatase_AS
PROSITE

PS00124--FBPASE
Pfam

PF00316--FBPase
Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0030018--C:Z disc
GO:0042132--F:fructose 1,6-bisphosphate 1-phosphatase activity
GO:0046872--F:metal ion binding
GO:0005975--P:carbohydrate metabolic process
GO:0006000--P:fructose metabolic process
GO:0006094--P:gluconeogenesis
GO:0006006--P:glucose metabolic process
GO:0044281--P:small molecule metabolic process