dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000155
Uniprot Accession O00750; P3C2B_HUMAN; O95666; Q5SW99;
Genbank Protein ID NP_002637.3; XP_005245314.1; XP_011507932.1; XP_011507933.1; XP_011507934.1;
Genbank Nucleotide ID NM_002646.3; XM_005245257.1; XM_011509630.1; XM_011509631.1; XM_011509632.1;
Protein Name Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
Protein Synonyms/Alias
Gene Name PIK3C2B
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
Phosphorylation Sites
 dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
2------MSSTQGNGEPHOSIDA21081558
3-----MSSTQGNGEHPHOSIDA21081558
4----MSSTQGNGEHWPHOSIDA;PhosphoSitePlus21081558; 22135298
13GNGEHWKSLESVGISPhosphoSitePlus;curated22135298; 25627689
34AEALQMEYDALSRLRPhosphoSitePlus22135298
68DEPGVDFYSKPAGRRPhosphoSitePlus;curated22135298; 22817900
69EPGVDFYSKPAGRRTPhosphoSitePlus22135298
76SKPAGRRTDLKLLRGPHOSIDA21081558
85LKLLRGLSGSDPTLNPHOSIDA21081558
115SQGPQPGSDPWPKGSPhosphoSitePlus22135298
127KGSLSGDYLYIFDGSPhosphoSitePlus;curated22135298; 22817900
155EGSCKKLSPPPLPPRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 18988627; 22135298; 19366988;
168PRASIWDTPPLPPRKPhosphoSitePlus22135298
177PLPPRKGSPSSSKISPhosphoSitePlus22135298
179PPRKGSPSSSKISQPPhosphoSitePlus22135298
228RLLGSVDYDGINDAIdbPTM 3.0;PhosphoSitePlus;curated17870612; 18180459; 19605366; 22322096; 16381945; 23193290;
293PRTYASRYGNRKNATPhosphoSitePlus22135298
469MEQKVVRSDLARTVNPhosphoSitePlus22135298
1056IVPRDCSYFNSNAVPdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
1148IQVEHGVTGSFKDRPPhosphoSitePlus22135298
Sequence
(Fasta)		MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHDKEENRAK QNADPSLISW 60
DEPGVDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSLSPQE GPPNHSTSQG PQPGSDPWPK 120
GSLSGDYLYI FDGSDGGVSS SPGPGDIEGS CKKLSPPPLP PRASIWDTPP LPPRKGSPSS 180
SKISQPSDIN TFSLVEQLPG KLLEHRILEE EEVLGGGGQG RLLGSVDYDG INDAITRLNL 240
KSTYDAEMLR DATRGWKEGR GPLDFSKDTS GKPVARSKTM PPQVPPRTYA SRYGNRKNAT 300
PGKNRRISAA PVGSRPHTVA NGHELFEVSE ERDEEVAAFC HMLDILRSGS DIQDYFLTGY 360
VWSAVTPSPE HLGDEVNLKV TVLCDRLQEA LTFTCNCSST VDLLIYQTLC YTHDDLRNVD 420
VGDFVLKPCG LEEFLQNKHA LGSHEYIQYC RKFDIDIRLQ LMEQKVVRSD LARTVNDDQS 480
PSTLNYLVHL QERPVKQTIS RQALSLLFDT YHNEVDAFLL ADGDFPLKAD RVVQSVKAIC 540
NALAAVETPE ITSALNQLPP CPSRMQPKIQ KDPSVLAVRE NREKVVEALT AAILDLVELY 600
CNTFNADFQT AVPGSRKHDL VQEACHFARS LAFTVYATHR IPIIWATSYE DFYLSCSLSH 660
GGKELCSPLQ TRRAHFSKYL FHLIVWDQQI CFPVQVNRLP RETLLCATLY ALPIPPPGSS 720
SEANKQRRVP EALGWVTTPL FNFRQVLTCG RKLLGLWPAT QENPSARWSA PNFHQPDSVI 780
LQIDFPTSAF DIKFTSPPGD KFSPRYEFGS LREEDQRKLK DIMQKESLYW LTDADKKRLW 840
EKRYYCHSEV SSLPLVLASA PSWEWACLPD IYVLLKQWTH MNHQDALGLL HATFPDQEVR 900
RMAVQWIGSL SDAELLDYLP QLVQALKYEC YLDSPLVRFL LKRAVSDLRV THYFFWLLKD 960
GLKDSQFSIR YQYLLAALLC CCGKGLREEF NRQCWLVNAL AKLAQQVREA APSARQGILR 1020
TGLEEVKQFF ALNGSCRLPL SPSLLVKGIV PRDCSYFNSN AVPLKLSFQN VDPLGENIRV 1080
IFKCGDDLRQ DMLTLQMIRI MSKIWVQEGL DMRMVIFRCF STGRGRGMVE MIPNAETLRK 1140
IQVEHGVTGS FKDRPLADWL QKHNPGEDEY EKAVENFIYS CAGCCVATYV LGICDRHNDN 1200
IMLKTTGHMF HIDFGRFLGH AQMFGNIKRD RAPFVFTSDM AYVINGGDKP SSRFHDFVDL 1260
CCQAYNLIRK HTHLFLNLLG LMLSCGIPEL SDLEDLKYVY DALRPQDTEA NATTYFTRLI 1320
ESSLGSVATK LNFFIHNLAQ MKFTGSDDRL TLSFASRTHT LKSSGRISDV FLCRHEKIFH 1380
PNKGYIYVVK VMRENTHEAT YIQRTFEEFQ ELHNKLRLLF PSSHLPSFPS RFVIGRSRGE 1440
AVAERRREEL NGYIWHLIHA PPEVAECDLV YTFFHPLPRD EKAMGTSPAP KSSDGTWARP 1500
VGKVGGEVKL SISYKNNKLF IMVMHIRGLQ LLQDGNDPDP YVKIYLLPDP QKTTKRKTKV 1560
ARKTCNPTYN EMLVYDGIPK GDLQQRELQL SVLSEQGFWE NVLLGEVNIR LRELDLAQEK 1620
TGWFALGSRS HGTL 1635
Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0418--Kinase
KW-0472--Membrane
KW-0492--Microsome
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR016024--ARM-type_fold
IPR000008--C2_dom
IPR011009--Kinase-like_dom
IPR001683--Phox
IPR000403--PI3/4_kinase_cat_dom
IPR018936--PI3/4_kinase_CS
IPR002420--PI3K_C2_dom
IPR000341--PI3K_Ras-bd_dom
IPR015433--PI_Kinase
IPR001263--PInositide-3_kin_accessory_dom
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50004--C2
PS00915--PI3_4_KINASE_1
PS00916--PI3_4_KINASE_2
PS50290--PI3_4_KINASE_3
PS51547--PI3K_C2
PS51546--PI3K_RBD
PS51545--PIK_HELICAL
PS50195--PX
Pfam

PF00168--C2
PF00454--PI3_PI4_kinase
PF00792--PI3K_C2
PF00794--PI3K_rbd
PF00613--PI3Ka
PF00787--PX
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030139--C:endocytic vesicle
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0005942--C:phosphatidylinositol 3-kinase complex
GO:0005886--C:plasma membrane
GO:0016303--F:1-phosphatidylinositol-3-kinase activity
GO:0035005--F:1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524--F:ATP binding
GO:0001727--F:lipid kinase activity
GO:0035091--F:phosphatidylinositol binding
GO:0002250--P:adaptive immune response
GO:0060326--P:cell chemotaxis
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0014065--P:phosphatidylinositol 3-kinase signaling
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0046854--P:phosphatidylinositol phosphorylation
GO:0036092--P:phosphatidylinositol-3-phosphate biosynthetic process
GO:0006644--P:phospholipid metabolic process
GO:0030168--P:platelet activation
GO:0043491--P:protein kinase B signaling
GO:0006468--P:protein phosphorylation
GO:0044281--P:small molecule metabolic process