dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000154
Uniprot Accession O00748; EST2_HUMAN; A8K367; Q16859; Q5MAB8; Q7Z366; Q8IUP4; Q8TCP8;
Genbank Protein ID NP_003860.2; NP_932327.1;
Genbank Nucleotide ID NM_003869.5; NM_198061.2;
Protein Name Cocaine esterase
Protein Synonyms/Alias Carboxylesterase 2;CE-2;hCE-2;
Gene Name CES2
Gene Synonyms/Alias ICE;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
38SPIRTTHTGQVLGSLPhosphoSitePlus22135298
368KEMDREASQAALQKMPhosphoSitePlus22135298
Sequence
(Fasta)		MRLHRLRARL SAVACGLLLL LVRGQGQDSA SPIRTTHTGQ VLGSLVHVKG ANAGVQTFLG 60
IPFAKPPLGP LRFAPPEPPE SWSGVRDGTT HPAMCLQDLT AVESEFLSQF NMTFPSDSMS 120
EDCLYLSIYT PAHSHEGSNL PVMVWIHGGA LVFGMASLYD GSMLAALENV VVVIIQYRLG 180
VLGFFSTGDK HATGNWGYLD QVAALRWVQQ NIAHFGGNPD RVTIFGESAG GTSVSSLVVS 240
PISQGLFHGA IMESGVALLP GLIASSADVI STVVANLSAC DQVDSEALVG CLRGKSKEEI 300
LAINKPFKMI PGVVDGVFLP RHPQELLASA DFQPVPSIVG VNNNEFGWLI PKVMRIYDTQ 360
KEMDREASQA ALQKMLTLLM LPPTFGDLLR EEYIGDNGDP QTLQAQFQEM MADSMFVIPA 420
LQVAHFQCSR APVYFYEFQH QPSWLKNIRP PHMKADHGDE LPFVFRSFFG GNYIKFTEEE 480
EQLSRKMMKY WANFARNGNP NGEGLPHWPL FDQEEQYLQL NLQPAVGRAL KAHRLQFWKK 540
ALPQKIQELE EPEERHTEL
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-0873--Pyrrolidone carboxylic acid
KW-1185--Reference proteome
KW-0719--Serine esterase
KW-0732--Signal
Interpro

IPR029058--AB_hydrolase
IPR002018--CarbesteraseB
IPR019826--Carboxylesterase_B_AS
IPR019819--Carboxylesterase_B_CS
PROSITE

PS00122--CARBOXYLESTERASE_B_1
PS00941--CARBOXYLESTERASE_B_2
Pfam

PF00135--COesterase
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005788--C:endoplasmic reticulum lumen
GO:0005615--C:extracellular space
GO:0052689--F:carboxylic ester hydrolase activity
GO:0047374--F:methylumbelliferyl-acetate deacetylase activity
GO:0009056--P:catabolic process
GO:0044281--P:small molecule metabolic process
GO:0006805--P:xenobiotic metabolic process