| Tag |
Content |
| dbPAF ID |
dbPAF-0000152 |
| Uniprot Accession |
O00744; WN10B_HUMAN; B2R7A5; O00747; Q4VAJ4; Q4VAJ5; Q8WZ97;
|
| Genbank Protein ID |
NP_003385.2; XP_011537025.1;
|
| Genbank Nucleotide ID |
NM_003394.3; XM_011538723.1;
|
| Protein Name |
Protein Wnt-10b |
| Protein Synonyms/Alias |
Protein Wnt-12; |
| Gene Name |
WNT10B |
| Gene Synonyms/Alias |
WNT12; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).Functional Description
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MLEEPRPRPP PSGLAGLLFL ALCSRALSNE ILGLKLPGEP PLTANTVCLT LSGLSKRQLG 60
LCLRNPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG GRLPHHSAIL KRGFRESAFS 120
FSMLAAGVMH AVATACSLGK LVSCGCGWKG SGEQDRLRAK LLQLQALSRG KSFPHSLPSP 180
GPGSSPSPGP QDTWEWGGCN HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT 240
ENLKRKCKCH GTSGSCQFKT CWRAAPEFRA VGAALRERLG RAIFIDTHNR NSGAFQPRLR 300
PRRLSGELVY FEKSPDFCER DPTMGSPGTR GRACNKTSRL LDGCGSLCCG RGHNVLRQTR 360
VERCHCRFHW CCYVLCDECK VTEWVNVCK
Fasta Sequence
>O00744|WNT10B|Homo sapiens(Human)
MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPRLRPRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0272--Extracellular matrix
KW-0325--Glycoprotein
KW-0449--Lipoprotein
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
KW-0879--Wnt signaling pathway
|
| Interpro |
IPR005817--Wnt
IPR013302--Wnt10
IPR018161--Wnt_CS
|
| PROSITE |
PS00246--WNT1
|
| Pfam |
PF00110--wnt
|
| Gene Ontology |
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0005578--C:proteinaceous extracellular matrix
GO:0005109--F:frizzled binding
GO:0048018--F:receptor agonist activity
GO:0060346--P:bone trabecula formation
GO:0060070--P:canonical Wnt signaling pathway
GO:0007050--P:cell cycle arrest
GO:0045165--P:cell fate commitment
GO:0071320--P:cellular response to cAMP
GO:0071374--P:cellular response to parathyroid hormone stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0002062--P:chondrocyte differentiation
GO:0061196--P:fungiform papilla development
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0071425--P:hematopoietic stem cell proliferation
GO:0006629--P:lipid metabolic process
GO:0014835--P:myoblast differentiation involved in skeletal muscle regeneration
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0045599--P:negative regulation of fat cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030182--P:neuron differentiation
GO:0051885--P:positive regulation of anagen
GO:0043065--P:positive regulation of apoptotic process
GO:0030501--P:positive regulation of bone mineralization
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0008284--P:positive regulation of cell proliferation
GO:0030858--P:positive regulation of epithelial cell differentiation
GO:0010971--P:positive regulation of G2/M transition of mitotic cell cycle
GO:0045669--P:positive regulation of osteoblast differentiation
GO:0045899--P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0050821--P:protein stabilization
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048641--P:regulation of skeletal muscle tissue development
GO:0050909--P:sensory perception of taste
GO:0048741--P:skeletal muscle fiber development
GO:0007224--P:smoothened signaling pathway
GO:0016055--P:Wnt signaling pathway
|
