| Tag |
Content |
| dbPAF ID |
dbPAF-0000151 |
| Uniprot Accession |
O00743; PPP6_HUMAN; B2R5V6; B7Z2W9; B7Z5K9; Q5U0A2; Q9UIC9;
|
| Genbank Protein ID |
NP_001116827.1; NP_001116841.1; NP_002712.1;
|
| Genbank Nucleotide ID |
NM_001123355.1; NM_001123369.1; NM_002721.4;
|
| Protein Name |
Serine/threonine-protein phosphatase 6 catalytic subunit |
| Protein Synonyms/Alias |
|
| Gene Name |
PPP6C |
| Gene Synonyms/Alias |
PPP6; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.Functional Description
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MAPLDLDKYV EIARLCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD 60
LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT 120
QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE 180
RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV 240
HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT 300
TPYFL
306Fasta Sequence
>O00743|PPP6C|Homo sapiens(Human)
MAPLDLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL
|
| Keyword |
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0464--Manganese
KW-0479--Metal-binding
KW-0904--Protein phosphatase
KW-1185--Reference proteome
|
| Interpro |
IPR004843--Calcineurin-like_PHP_apaH
IPR029052--Metallo-depent_PP-like
IPR006186--Ser/Thr-sp_prot-phosphatase
|
| PROSITE |
PS00125--SER_THR_PHOSPHATASE
|
| Pfam |
PF00149--Metallophos
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0046872--F:metal ion binding
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0044267--P:cellular protein metabolic process
GO:0048208--P:COPII vesicle coating
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0061024--P:membrane organization
GO:0043687--P:post-translational protein modification
GO:0006470--P:protein dephosphorylation
GO:0018279--P:protein N-linked glycosylation via asparagine
|
