dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000150
Uniprot Accession O00716; E2F3_HUMAN; Q15000; Q68DT0; Q9BZ44;
Genbank Protein ID NP_001230005.1; NP_001940.1;
Genbank Nucleotide ID NM_001243076.2; NM_001949.4;
Protein Name Transcription factor E2F3
Protein Synonyms/Alias
Gene Name E2F3
Gene Synonyms/Alias KIAA0075;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 12
PositionPeptidesSourceReferences ( PMIDs )
124PALGRGGSGGGGGPPdbPTM 3.0;PhosphoSitePlus;curated19917728; 16381945; 23193290; 22135298; 22817900
152YLSDGLKTPKGKGRAPhosphoSitePlus22135298
163KGRAALRSPDSPKTPdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298; 25627689; 23898821;
166AALRSPDSPKTPKSPdbPTM 3.0;PhosphoSitePlus;curated20363803; 16381945; 23193290; 22135298; 25627689; 23898821;
169RSPDSPKTPKSPSEKPhosphoSitePlus;curated22135298; 25627689; 21857030; 26074081
172DSPKTPKSPSEKTRYPhosphoSitePlus;curated22135298; 25627689; 25003641; 21857030; 26074081
174PKTPKSPSEKTRYDTPhosphoSitePlus22135298
179SPSEKTRYDTSLGLLdbPTM 3.0;Phospho.ELM 9.0;curated18669648; 16381945; 23193290; 22817900
182EKTRYDTSLGLLTKKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;curated18669648; 16381945; 23193290; 18988627; 22817900
235IHLIKKKSKNNVQWMPhosphoSitePlus22135298
349TQGPIEVYLCPEETEPhosphoSitePlus22135298
359PEETETHSPMKTNNQcurated25627689
Sequence
(Fasta)		MRKGIQPALE QYLVTAGGGE GAAVVAAAAA ASMDKRALLA SPGFAAAAAA AAAPGAYIQI 60
LTTNTSTTSC SSSLQSGAVA AGPLLPSAPG AEQTAGSLLY TTPHGPSSRA GLLQQPPALG 120
RGGSGGGGGP PAKRRLELGE SGHQYLSDGL KTPKGKGRAA LRSPDSPKTP KSPSEKTRYD 180
TSLGLLTKKF IQLLSQSPDG VLDLNKAAEV LKVQKRRIYD ITNVLEGIHL IKKKSKNNVQ 240
WMGCSLSEDG GMLAQCQGLS KEVTELSQEE KKLDELIQSC TLDLKLLTED SENQRLAYVT 300
YQDIRKISGL KDQTVIVVKA PPETRLEVPD SIESLQIHLA STQGPIEVYL CPEETETHSP 360
MKTNNQDHNG NIPKPASKDL ASTNSGHSDC SVSMGNLSPL ASPANLLQQT EDQIPSNLEG 420
PFVNLLPPLL QEDYLLSLGE EEGISDLFDA YDLEKLPLVE DFMCS 466
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR015633--E2F
IPR032198--E2F_CC-MB
IPR003316--E2F_WHTH_DNA-bd_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE
Pfam

PF16421--E2F_CC-MB
PF02319--E2F_TDP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005667--C:transcription factor complex
GO:0001047--F:core promoter binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000278--P:mitotic cell cycle
GO:0070345--P:negative regulation of fat cell proliferation
GO:0007219--P:Notch signaling pathway
GO:0008284--P:positive regulation of cell proliferation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006367--P:transcription initiation from RNA polymerase II promoter